Department of Computational and Systems Biology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Clin Transl Med. 2024 Jul;14(7):e1769. doi: 10.1002/ctm2.1769.
Recently, there is a rise in studies that recognize the importance of targeting ubiquitin and related molecular machinery in various therapeutic contexts. Here we briefly discuss the history of ubiquitin, its biological roles in protein degradation and beyond, as well as the current state of ubiquitin-targeting therapeutics across diseases. We conclude that targeting ubiquitin machinery is approaching a renaissance, and tapping its full potential will require embracing a wholistic perspective of ubiquitin's multifaceted roles.
最近，越来越多的研究认识到靶向泛素及相关分子机制在各种治疗环境中的重要性。在这里，我们简要讨论泛素的历史、它在蛋白质降解及其他方面的生物学作用，以及泛素靶向治疗在各种疾病中的现状。我们得出结论，靶向泛素机制正在迎来复兴，充分发挥其潜力需要采用泛素多方面作用的整体观点。
