Kitano Hiromi, Nasu Motomi, Hashimoto Takashi, Tsurumaru Masahiko, Kajiyama Yoshiaki
Juntendo Iji Zasshi. 2022 Aug 1;68(4):369-374. doi: 10.14789/jmj.JMJ21-0049-OA. eCollection 2022.
In recent years, circulating tumor cells (CTCs) have attracted attention for prediction of metastasis in breast, prostate, and colon cancers. This study aimed to investigate whether detection of CTCs could be prognostic factor in esophageal cancer.
This study involved 38 patients treated at Juntendo University from May 2010 to April 2013 who provided consent. CTCs were measured using CellSearch system in preoperative peripheral blood. Clinicopathological parameters and prognostic factors were retrieved from our medical records.
CTCs were detected in 6 of 38 patients (15.8%). Among patients' characteristics and clinicopathological features, CTC-positive group had higher serum SCC levels and tended to have more advanced cStages than the CTC-negative group. The CTC-negative group showed better survival curves than CTCs positive-group in both overall survival (OS) and disease-free survival (DFS) although the differences were not statistically significant. CTCs positivity has a possibility to be prognostic marker according to multivariable analysis of OS and DFS.
Although this study has some limitations, our results suggest that CTCs in preoperative peripheral blood has potential to be a prognostic marker for esophageal cancer.
近年来，循环肿瘤细胞（CTC）在乳腺癌、前列腺癌和结肠癌转移预测方面受到关注。本研究旨在探讨检测CTC是否可作为食管癌的预后因素。
本研究纳入了2010年5月至2013年4月在顺天堂大学接受治疗并签署知情同意书的38例患者。术前采用CellSearch系统检测外周血中的CTC。从我们的病历中获取临床病理参数和预后因素。
38例患者中有6例检测到CTC（15.8%）。在患者特征和临床病理特征方面，CTC阳性组的血清鳞状细胞癌（SCC）水平较高，且c期往往比CTC阴性组更晚。尽管差异无统计学意义，但在总生存期（OS）和无病生存期（DFS）方面，CTC阴性组的生存曲线均优于CTC阳性组。根据OS和DFS的多变量分析，CTC阳性有可能成为预后标志物。
尽管本研究存在一些局限性，但我们的结果表明，术前外周血中的CTC有可能成为食管癌的预后标志物。
