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Sag deletion promotes DMBA/TPA-induced skin carcinogenesis via YAP accumulation.

作者信息

Sun Yi, Xu Jie, Wei Dongping, Li Hua

机构信息

Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education) of the Second Affiliated Hospital, and Institute of Translational Medicine, Zhejiang University School of Medicine Hangzhou China.

Research Center for Life Science and Human Health of Binjiang Institute Zhejiang University Hangzhou China.

出版信息

MedComm (2020). 2024 Jul 17;5(8):e648. doi: 10.1002/mco2.648. eCollection 2024 Aug.

DOI:10.1002/mco2.648
PMID:39021515
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11253290/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48b9/11253290/9477e75faff4/MCO2-5-e648-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48b9/11253290/9477e75faff4/MCO2-5-e648-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/48b9/11253290/9477e75faff4/MCO2-5-e648-g001.jpg

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本文引用的文献

1
The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model.在Kras胰腺肿瘤模型中，Sag-Shoc2轴调节胰腺上皮内瘤变向囊性病变的转化。
Cell Rep. 2022 Dec 20;41(12):111837. doi: 10.1016/j.celrep.2022.111837.
2
Transgenic expression of Sag/Rbx2 E3 causes early stage tumor promotion, late stage cytogenesis and acinar loss in the Kras-PDAC model.Sag/Rbx2 E3的转基因表达在Kras-PDAC模型中导致早期肿瘤促进、晚期细胞生成和腺泡丢失。
Neoplasia. 2020 Apr 24;22(6):242-252. doi: 10.1016/j.neo.2020.03.002.
3
Erbin is a novel substrate of the Sag-βTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesis.
Erbin是Sag-βTrCP E3连接酶的一种新型底物，该连接酶可调节KrasG12D诱导的皮肤肿瘤发生。
J Cell Biol. 2015 Jun 8;209(5):721-37. doi: 10.1083/jcb.201411104.
4
Inactivation of SAG/RBX2 E3 ubiquitin ligase suppresses KrasG12D-driven lung tumorigenesis.SAG/RBX2 E3 泛素连接酶的失活抑制 KrasG12D 驱动的肺肿瘤发生。
J Clin Invest. 2014 Feb;124(2):835-46. doi: 10.1172/JCI70297. Epub 2014 Jan 16.
5
SAG/ROC2 E3 ligase regulates skin carcinogenesis by stage-dependent targeting of c-Jun/AP1 and IkappaB-alpha/NF-kappaB.SAG/ROC2 E3 连接酶通过对 c-Jun/AP1 和 IkappaB-α/NF-kappaB 的阶段依赖性靶向作用来调节皮肤癌发生。
J Cell Biol. 2007 Sep 10;178(6):1009-23. doi: 10.1083/jcb.200612067.