Sandoval-Ato Raúl, Coral-Gonzales Patricia, Coronel-Arias Sebastian, Espinoza-Mantilla Luisa, Terrones-Chaparro Grace, Serna-Alarcón Victor
Escuela de Posgrado, Facultad de Medicina, Universidad Privada Antenor Orrego, Trujillo 13008, Perú.
Unidad de Investigación Clínica, Scientia Clinical and Epidemiological Research Institute, Trujillo 13001, Perú.
Ecancermedicalscience. 2024 Jun 27;18:1720. doi: 10.3332/ecancer.2024.1720. eCollection 2024.
Triple-negative breast cancer (TNBC) has an aggressive clinical behaviour, with advanced stages at initial diagnostic evaluation, early recurrences and poor survival, so the purpose was to determine the clinical and radiological manifestations associated with TNBC.
A case-control study in women diagnosed with breast cancer from January 2015 to August 2022 at the 'Instituto Regional de Enfermedades Neoplásicas del Norte'. We classified cases (Triple Negative subtype) and controls (Luminal A, Luminal B and HER2) according to immunohistochemistry ical analysis. Bivariate and multivariate logistic regression models were used to calculate the odds ratio (OR) with their respective 95% confidence intervals (CIs).
The medical reports of 88 cases and 236 controls were reviewed. Cases were more likely to report pain ( = 0.001), nodules on ultrasound ( = 0.01) and mammography ( = 0.003), superior median size ( < 0.05), posterior enhancement ( = 0.001) and moderate density ( = 0.003). Multivariate analysis identified that TNBC was more likely to have a nodular type lesion by ultrasound (OR: 9.73, 95% CI: 1.10-86.16; = 0.04), ultrasound lesion larger than 36 mm (OR: 4.99, 95% CI: 1.75-14.17; = 0.003) and moderate density (OR: 3.83, 95% CI: 1.44-10.14; = 0.007).
There are particular clinical and imaging manifestations of TNBC, showing that radiological lesions that presented characteristics in ultrasound as nodular type lesions larger than 36 mm and in mammography moderate grade density, were associated with this subtype of breast tumours in a Peruvian population.
三阴性乳腺癌（TNBC）具有侵袭性临床行为，在初次诊断评估时处于晚期阶段，复发早且生存率低，因此目的是确定与TNBC相关的临床和放射学表现。
对2015年1月至2022年8月在“北地区肿瘤疾病研究所”被诊断为乳腺癌的女性进行病例对照研究。我们根据免疫组织化学分析对病例（三阴性亚型）和对照（管腔A型、管腔B型和HER2型）进行分类。使用二元和多元逻辑回归模型计算比值比（OR）及其各自的95%置信区间（CI）。
回顾了88例病例和236例对照的医学报告。病例更有可能报告疼痛（P = 0.001）、超声检查发现结节（P = 0.01）和乳腺X线摄影发现结节（P = 0.003）、中位尺寸较大（P < 0.05）、后方增强（P = 0.001）和密度中等（P = 0.003）。多变量分析确定，TNBC更有可能通过超声检查发现结节型病变（OR：9.73，95%CI：1.10 - 86.16；P = 0.04）、超声病变大于36毫米（OR：4.99，95%CI：1.75 - 14.17；P = 0.003）和密度中等（OR：3.83，95%CI：1.44 - 10.14；P = 0.007）。
TNBC存在特定的临床和影像学表现，表明在秘鲁人群中，超声检查表现为大于36毫米的结节型病变且乳腺X线摄影显示密度中等的放射学病变与这种乳腺肿瘤亚型相关。
