Rasheed Fatima Abubakar, Yakasai Ibrahim Adamu, Abdurrahman Aisha, Usman Asma'u, Yusuf Nafisat
Department of Obstetrics and Gynaecology, Federal Teaching Hospital, Katsina 820101, Nigeria.
https://orcid.org/0000-0002-2398-516X.
Ecancermedicalscience. 2024 Jun 13;18:1714. doi: 10.3332/ecancer.2024.1714. eCollection 2024.
Cervical cancer is the leading cause of gynaecological cancer death among women in developing countries and the most preventable of all gynaecological cancers as its infectious aetiological agent, human papillomavirus (HPV), is known. The knowledge of HPV serotype distribution in a sub-region is key to the implementation of an appropriate HPV vaccination programme.
To assess the prevalence of HPV-DNA, serotypes and risk-determinants among women with invasive cervical cancer (ICC) in Katsina State, Northwestern Nigeria.
This was a cross-sectional, multicenter study involving Federal Teaching Hospital Katsina, General Hospital Katsina and Turai Yar'adua Maternal and Child Hospital Katsina, Nigeria. Sixty-three women with histologically confirmed cervical cancer who fulfilled the criteria were recruited into the study. Tissue blocks with a confirmed diagnosis of ICC were taken to DNA Labs Kaduna for HPV-deoxyribonucleotide acid detection and typing. An interviewer-administered questionnaire developed for the study was used to obtain socio-demographic, reproductive characteristics and the other risk factors for HPV acquisition and persistence.
The HPV-positivity rate in ICC was 95.5% while the prevalence of high-risk HPV (Hr-HPV)-DNA in the specimen was 54.6% with 13 HPV-serotypes detected, 9 Hr-HPV types (16,18,31,33,35,45,51,56,82) and 4 low-risk HPV types (6,44,81,89). The most commonly detected HPV serotype among women with a single HPV infection was HPV 81 (40.9%) followed by HPV 16 (28.8%). However, HPV 16 was the most common serotype among those with multiple HPV infections. Prevalence of other detected serotypes were HPV 31 (24.2%), 33 (24.2%), HPV 18 (10.6%), HPV 35 (3.0%), HPV 45 (9.1%), HPV 44 (1.5%), HPV 51 (3.0%), HPV 56 (3.0%), HPV 82 (1.5%), HPV 89 (1.5%) and HPV 6 (1.5%). Forty-four out of 63 women (69.8%) had a single HPV infection, 19 (30.2%) had multiple HPV infections and 15 (24.3%) were co-infected with HPV 16/31/33. There was a statistically significant association between HPV 16 and squamous cell carcinoma (SCC).
The study demonstrates a prevalence of HPV-DNA as 95.5% among women with ICC. The most commonly detected HPV serotype was HPV 81 seen in 41% which was an uncommon finding. Furthermore, statistically significant associations between HPV serotypes 16 and 82 with SCC were detected.
宫颈癌是发展中国家女性妇科癌症死亡的主要原因，并且是所有妇科癌症中最可预防的，因为其感染性病因——人乳头瘤病毒（HPV）已为人所知。了解一个次区域内HPV血清型分布情况是实施适当HPV疫苗接种计划的关键。
评估尼日利亚西北部卡齐纳州浸润性宫颈癌（ICC）女性中HPV-DNA、血清型及风险决定因素的流行情况。
这是一项横断面多中心研究，涉及尼日利亚卡齐纳州的联邦教学医院、卡齐纳综合医院以及图赖·亚拉杜瓦妇幼医院。63名经组织学确诊宫颈癌且符合标准的女性被纳入研究。确诊为ICC的组织块被送往卡杜纳DNA实验室进行HPV脱氧核糖核酸检测和分型。一份为该研究专门设计的由访谈者实施的问卷被用于获取社会人口统计学、生殖特征以及其他HPV感染和持续存在的风险因素。
ICC中HPV阳性率为95.5%，标本中高危型HPV（Hr-HPV）-DNA的流行率为54.6%，共检测到13种HPV血清型，9种高危型HPV（16、18、31、33、35、45、51、56、82）和4种低危型HPV（6、44、81、89）。在单一HPV感染的女性中最常检测到的HPV血清型是HPV 81（40.9%），其次是HPV 16（28.8%）。然而，HPV 16是多重HPV感染女性中最常见的血清型。其他检测到的血清型流行率分别为HPV 31（24.2%）、33（24.2%）、HPV 18（10.6%）、HPV 35（3.0%）、HPV 45（9.1%）、HPV 44（1.5%）、HPV 51（3.0%）、HPV 56（3.0%）、HPV 82（1.5%）、HPV 89（1.5%）和HPV 6（1.5%）。63名女性中有44名（69.8%）为单一HPV感染，19名（30.2%）为多重HPV感染，15名（24.3%）同时感染了HPV 16/31/33。HPV 16与鳞状细胞癌（SCC）之间存在统计学显著关联。
该研究表明ICC女性中HPV-DNA流行率为95.5%。最常检测到的HPV血清型是HPV 81，占41%，这是一个不常见的发现。此外，还检测到HPV血清型16和82与SCC之间存在统计学显著关联。
