Loganathan Tamil Selvi, Sulaiman Siti Aishah, Abdul Murad Nor Azian, Shah Shamsul Azhar, Abdul Gafor Abdul Halim, Jamal Rahman, Abdullah Noraidatulakma
UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Department of Community Health, UKM Medical Centre, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
Front Pharmacol. 2020 Mar 3;11:191. doi: 10.3389/fphar.2020.00191. eCollection 2020.
Diabetic Nephropathy (DN) is the most common cause of End-stage renal disease (ESRD). Although various treatments and diagnosis applications are available, DN remains a clinical and economic burden. Recent findings showed that noncoding RNAs (ncRNAs) play an important role in DN progression, potentially can be used as biomarkers and therapeutic targets. NcRNAs refers to the RNA species that do not encode for any protein, and the most known ncRNAs are the microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). Dysregulation of these ncRNAs was reported before in DN patients and animal models of DN. Importantly, there are some interactions between these ncRNAs to regulate the crucial steps in DN progression. Here, we aimed to discuss the reported ncRNAs in DN and their interactions with critical genes in DN progression. Elucidating these ncRNAs regulatory network will allow for a better understanding of the molecular mechanisms in DN and how they can act as new biomarkers for DN and also as the potential targets for treatment.
糖尿病肾病（DN）是终末期肾病（ESRD）最常见的病因。尽管有各种治疗方法和诊断应用，但DN仍然是一个临床和经济负担。最近的研究结果表明，非编码RNA（ncRNAs）在DN进展中起重要作用，有可能用作生物标志物和治疗靶点。NcRNAs是指不编码任何蛋白质的RNA种类，最知名的ncRNAs是微小RNA（miRNAs）、长链非编码RNA（lncRNAs）和环状RNA（circRNAs）。之前在DN患者和DN动物模型中报道过这些ncRNAs的失调。重要的是，这些ncRNAs之间存在一些相互作用，以调节DN进展中的关键步骤。在此，我们旨在讨论DN中已报道的ncRNAs及其在DN进展中与关键基因的相互作用。阐明这些ncRNAs调控网络将有助于更好地理解DN的分子机制，以及它们如何作为DN的新生物标志物和潜在治疗靶点。
