Kherrab Anass, Toufik Hamza, Ghazi Mirieme, Benhima Mohamed Amine, Chbihi-Kaddouri Anass, Chergaoui Ilyass, Niamane Radouane, El Maghraoui Abdellah
Department of Rheumatology, Avicenne Military Hospital, Cadi Ayyad University, Marrakesh, Morocco.
Department of Rheumatology, Mohammed V Military Hospital, Mohammed V University, Rabat, Morocco.
Arch Osteoporos. 2024 Jul 18;19(1):61. doi: 10.1007/s11657-024-01421-3.
This systematic review and meta-analysis was conducted as part of the update of Moroccan recommendations for the management of postmenopausal osteoporosis. Its aim was to estimate the prevalence of postmenopausal osteoporosis in Morocco, based on available bibliographic data.
We conducted a systematic search of the Medline/PubMed, Scopus, and Embase databases to identify articles published between January 2000 and January 2024. We included all observational studies reporting the prevalence of osteoporosis in postmenopausal women in Morocco. Two reviewers independently contributed to the study selection and data extraction. We assessed the risk of bias in the included studies using the Joanna Briggs Institute tool. Statistical analyses were performed using Stata with the Freeman-Tukey double arcsine transformation. Heterogeneity was assessed using the I test statistic. Meta-regression analysis was used to investigate the effect of the date on the prevalence. Publication bias was assessed by DOI plots and the LFK index.
An electronic search found a total of 161 citations from the databases. After excluding the irrelevant articles, 17 eligible studies were included. This meta-analysis included 5097 postmenopausal women. The pooled prevalence of postmenopausal osteoporosis was 32% (95% CI 28-36). Heterogeneity was statistically significant (I = 89.67%). There was no significant difference between subgroup analyses performed by risk of bias and sample size. The prevalence rate was significantly higher in 2006-2012 (36%; 95% CI 31-42; I = 88.7%; p < 0.001) than in 2013-2019 (27%; 95% CI 22-32; I = 85.9%; p < 0.001). Meta-regression showed that the prevalence of osteoporosis decreases very slightly (0.016% per year). This decrease becomes nonsignificant if only studies with a low risk of bias are included in the meta-regression (coefficient - 7.77, p = 0.667, I 0%). No publication bias was detected in this meta-analysis.
Our results indicate that postmenopausal osteoporosis is prevalent in Morocco, which is a developing country; however, the prevalence of this disease is aligned with that of industrialized countries.
本系统评价和荟萃分析是作为摩洛哥绝经后骨质疏松症管理建议更新的一部分进行的。其目的是根据现有文献数据估计摩洛哥绝经后骨质疏松症的患病率。
我们对Medline/PubMed、Scopus和Embase数据库进行了系统检索，以识别2000年1月至2024年1月期间发表的文章。我们纳入了所有报告摩洛哥绝经后妇女骨质疏松症患病率的观察性研究。两名评审员独立参与研究选择和数据提取。我们使用乔安娜·布里格斯研究所工具评估纳入研究的偏倚风险。使用Stata并采用弗里曼-图基双反正弦变换进行统计分析。使用I检验统计量评估异质性。荟萃回归分析用于研究日期对患病率的影响。通过DOI图和LFK指数评估发表偏倚。
电子检索共从数据库中找到161条引文。排除无关文章后，纳入了17项符合条件的研究。该荟萃分析纳入了5097名绝经后妇女分组分析。绝经后骨质疏松症的合并患病率为32%（95%CI 28-36）。异质性具有统计学意义（I=89.67%）。按偏倚风险和样本量进行的亚组分析之间无显著差异。2006-2012年的患病率（36%；95%CI 31-42；I=88.7%；p<0.001）显著高于2013-2019年（27%；95%CI 22-32；I=85.9%；p<0.001）。荟萃回归显示骨质疏松症的患病率每年略有下降（0.016%）。如果荟萃回归中仅纳入偏倚风险低的研究，这种下降就变得不显著（系数-7.77，p=0.667，I 0%）。本荟萃分析未检测到发表偏倚。
我们的结果表明，绝经后骨质疏松症在摩洛哥这个发展中国家很普遍；然而，这种疾病的患病率与工业化国家一致。
