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儿科透析单位监测儿童贫血管理和铁状态的关键绩效指标:艾因夏姆斯大学的经验。

Key performance indicators for monitoring of anemia management and iron status in children attending a pediatric dialysis unit: the experience of Ain Shams University.

机构信息

Division of Pediatric Nephrology, Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Department of Community, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

出版信息

J Nephrol. 2024 Sep;37(7):1967-1972. doi: 10.1007/s40620-024-02017-3. Epub 2024 Jul 18.

Abstract

BACKGROUND

Anemia in children on maintenance hemodialysis (HD) leads to poor quality of life. Our study aimed to assess and monitor anemia and iron status management in children on maintenance HD over 18 months using key performance indicators.

METHODS

Key performance indicators, formulated as the percentage of patients achieving the KDIGO (2012) guideline-recommended targets for hemoglobin (Hb) (11-12 g/dl), transferrin saturation (TSAT) (20-40%) and serum ferritin (200-500 ng/ml), were reported quarterly over the 18-month-period of this study.

RESULTS

This study was carried out over an 18 month-period, from April 1st, 2020, till October 31st, 2021. A total of 78 patients (45 males and 33 females) were included; mean age 12.16 ± 3.3 years and HD duration range 3.0-140.88 months, median 16.51 months. The three most common primary causes of CKD were Congenital Anomalies of the Kidney and Urinary Tract (CAKUT) (29.5%), unknown cause (24.4%), and chronic glomerular diseases (20.5%). The quarterly reported percentages of patients achieving the recommended targets for Hb, TSAT, and serum ferritin ranges were 18.2-35.7%, 38.8-57.1%, and 11.9-26.6%, respectively.

CONCLUSION

Although the mean Hb trend was nearing the KDIGO (2012) target, the key performance indicators showed that only a small percentage of our HD patients were achieving the targets for Hb, TSAT, & serum ferritin, thus alerting us to the need to revise our protocol for the management of anemia and iron status.

摘要

背景

维持性血液透析(HD)患儿的贫血会导致生活质量下降。我们的研究旨在使用关键绩效指标评估和监测维持性 HD 患儿 18 个月以上的贫血和铁状态管理。

方法

关键绩效指标以患者达到 KDIGO(2012)指南推荐的血红蛋白(Hb)(11-12g/dl)、转铁蛋白饱和度(TSAT)(20-40%)和血清铁蛋白(200-500ng/ml)目标的百分比表示,在研究的 18 个月期间每季度报告一次。

结果

这项研究持续了 18 个月,从 2020 年 4 月 1 日到 2021 年 10 月 31 日。共纳入 78 例患者(45 名男性和 33 名女性);平均年龄为 12.16±3.3 岁,HD 持续时间范围为 3.0-140.88 个月,中位数为 16.51 个月。CKD 的三个最常见的主要病因是肾脏和泌尿道先天异常(CAKUT)(29.5%)、原因不明(24.4%)和慢性肾小球疾病(20.5%)。每季度报告的达到 Hb、TSAT 和血清铁蛋白推荐目标的患者百分比分别为 18.2-35.7%、38.8-57.1%和 11.9-26.6%。

结论

尽管平均 Hb 趋势接近 KDIGO(2012)目标,但关键绩效指标显示,只有一小部分 HD 患者达到了 Hb、TSAT 和血清铁蛋白的目标,这提醒我们需要修订贫血和铁状态管理的方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ac5/11519122/352f7c96bd36/40620_2024_2017_Fig1_HTML.jpg

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