Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal.
Front Cell Infect Microbiol. 2024 Jul 4;14:1367998. doi: 10.3389/fcimb.2024.1367998. eCollection 2024.
Ulcerative colitis is an inflammatory disorder characterized by chronic inflammation in the gastrointestinal tract, mainly in the colon and rectum. Although the precise etiology of ulcerative colitis remains unclear, recent research has underscored the significant role of the microbiome in its development and progression.
The aim of this study was to establish a relationship between the levels of specific gut bacterial species and disease relapse in ulcerative colitis. For this study, we recruited 105 ulcerative colitis patients in remission and collected clinical data, blood, and stool samples. and levels were quantified in the stool samples of ulcerative colitis patients. Binary logistic regression was applied to collected data to predict disease remission.
The median time in remission in this cohort was four years. A predictive model incorporating demographic information, clinical data, and the levels of and was developed to understand remission patterns.
Our findings revealed a negative correlation between the levels of these two microorganisms and the duration of remission. These findings highlight the importance of the gut microbiota in ulcerative colitis for disease prognosis and for personalized treatments based on microbiome interventions.
溃疡性结肠炎是一种炎症性疾病，其特征为胃肠道（主要是结肠和直肠）慢性炎症。尽管溃疡性结肠炎的确切病因仍不清楚，但最近的研究强调了微生物组在其发展和进展中的重要作用。
本研究旨在建立特定肠道细菌种类的水平与溃疡性结肠炎复发之间的关系。为此，我们招募了 105 名处于缓解期的溃疡性结肠炎患者，并收集了临床数据、血液和粪便样本。在溃疡性结肠炎患者的粪便样本中定量检测 和 的水平。采用二元逻辑回归对收集的数据进行分析，以预测疾病缓解。
本队列的中位缓解时间为四年。我们建立了一个包含人口统计学信息、临床数据和 和 水平的预测模型，以了解缓解模式。
我们的发现揭示了这两种微生物的水平与缓解时间之间存在负相关关系。这些发现强调了肠道微生物组在溃疡性结肠炎疾病预后中的重要性，以及基于微生物组干预的个体化治疗的重要性。
