对象的社会人口统计学特征影响了内罗毕县 5 岁以下儿童中肠致病性大肠杆菌病原型的传播模式。
Subjects' Sociodemographics Influence the Transmission Patterns of Diarrheagenic Escherichia coli Pathotypes among Children under 5 Years in Nakuru County.
机构信息
Department of Environmental Health and Disease Control, School of Public Health, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya.
Department of Pharmacology and Pharmacognosy, Kabarak University, Nakuru, Kenya.
出版信息
Ann Afr Med. 2024 Apr 1;23(2):132-139. doi: 10.4103/aam.aam_41_23. Epub 2023 Nov 10.
BACKGROUND
Diarrheagenic Escherichiacoli (DEC) infections constitute the leading causes of morbidity and mortality among children in Sub-Saharan Africa. However, little has so far been done to properly reveal the pathogenic endowments of DEC in these populations.
AIMS AND OBJECTIVES
We evaluated 4 DEC strains among children under 5 years.
MATERIALS AND METHODS
A cross-sectional study design was employed among 384 positive cases.
RESULTS
There was a significant decline in infections associated with DEC as the children grew older (χ2[12] = 87.366: P = [0.000]. A total of 56 (14.6%) cases were 0-12 months, 168 (43.8%) were 13-24 months, 88 (22.9%) were 25-36 months, 40 (10.4%) were 37-48 months, and 32 (8.3%) were 49-60 months. A total of 248 (64.6%) male subjects exhibited more susceptibility to DEC infections than their female counterparts (n = 136 [35.4%]) (χ2[3] =13.313: P = [0.004]. Subjects from urban areas (n = 248 [64.6%]), significantly bored the brunt of infections than those from rural areas (n = 136 [35.4%]) (χ2[3] = 35.147: P = [0.000]. The prevalence of DEC appeared significantly higher during rainy seasons (n = 269 [70.1%]).
CONCLUSION
Young age, male gender, crowding, and rainy season play a central role in the transmission of DEC pathotypes.
背景
肠致病性大肠杆菌（DEC）感染是撒哈拉以南非洲儿童发病率和死亡率的主要原因。然而，迄今为止，人们在适当揭示这些人群中 DEC 的致病能力方面做得还很少。
目的和目标
我们评估了 5 岁以下儿童中的 4 株 DEC 菌株。
材料和方法
采用横断面研究设计，对 384 例阳性病例进行研究。
结果
随着儿童年龄的增长，与 DEC 相关的感染显著下降（χ2[12] = 87.366：P = [0.000]）。共有 56 例（14.6%）为 0-12 个月，168 例（43.8%）为 13-24 个月，88 例（22.9%）为 25-36 个月，40 例（10.4%）为 37-48 个月，32 例（8.3%）为 49-60 个月。共有 248 例（64.6%）男性比女性更容易感染 DEC（n = 136 [35.4%]）（χ2[3] = 13.313：P = [0.004]）。来自城市地区的患者（n = 248 [64.6%]）比来自农村地区的患者（n = 136 [35.4%]）更易受到感染（χ2[3] = 35.147：P = [0.000]）。DEC 的患病率在雨季显著升高（n = 269 [70.1%]）。
结论
年龄小、男性、拥挤和雨季在 DEC 血清型传播中起着核心作用。
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