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接受内镜下腰椎间盘切除术治疗的腰椎间盘突出症患者腹主动脉钙化与临床结局的关联

Association of Abdominal Aortic Calcification and Clinical Outcomes in LDH Patients Treated with Endoscopic Lumbar Discectomy.

作者信息

Zhang Ying, Zhu Zhaoji, Jin Xiaohong, Huang Peng

机构信息

Department of Pain, The First Affiliated Hospital of Soochow University, Pinghai Road NO. 899, Suzhou City, Jiangsu Province, China.

Department of General Practice, Changshu Hospital Affiliated to Soochow University, Suzhou, China.

出版信息

Pain Ther. 2024 Oct;13(5):1257-1269. doi: 10.1007/s40122-024-00633-2. Epub 2024 Jul 19.

Abstract

INTRODUCTION

To determine any significant associations between abdominal aortic calcification (AAC) and clinical manifestations of pain symptoms following endoscopic lumbar discectomy.

METHODS

Patients sequentially presenting with a history of unilateral radiculopathy with or without back pain, and with magnetic resonance imaging (MRI)-confirmed diagnosis of posterolateral disc herniation between August 2021 and December 2023 were eligible for inclusion in the study. All patients underwent endoscopic discectomy at our center during the study period. AAC stages were classified based on the Kauppila classification system using lateral lumbar radiographs.

RESULTS

Between August 2021 and December 2023 a total of 120 patients were included in the study for analysis, of whom 82 (68.3%) exhibited mild AAC and 38 (31.7%) had moderate-severe AAC. Analyses using the multivariate linear regression model revealed a significant correlation between AAC comorbidity and postoperative clinical outcomes. At 1 year post-surgery, the mean change in leg pain following endoscopic lumbar discectomy was significantly less for patients with moderate-severe AAC (5.0 points) than for patients with mild ACC (p < 0.001). Even after adjusting for relevant confounders, this difference remained significant. Similar results were also observed in the postoperative improvement of back pain, the Oswestry Disability Index score, and the physical functioning, role physical, and bodily pain components of the 36-item Short Form Health Survey questionnaire. There was no significant difference in the rate of repeat surgery or post-surgical new-onset back pain between patients with different levels of severity of AAC at 1 year post-surgery.

CONCLUSIONS

There is a significant association between the severity of AAC and clinical outcomes among patients with lumbar disk herniation who underwent endoscopic lumbar discectomy. AAC may serve as a prognostic factor in predicting surgical outcomes and guiding management strategies for patients with lumbar disk herniation following endoscopic lumbar discectomy.

摘要

引言

确定腹主动脉钙化(AAC)与内镜下腰椎间盘切除术后疼痛症状临床表现之间的任何显著关联。

方法

2021年8月至2023年12月期间,有单侧神经根病病史(伴或不伴背痛)且经磁共振成像(MRI)确诊为后外侧椎间盘突出的患者符合纳入本研究的条件。在研究期间,所有患者均在我们中心接受了内镜下椎间盘切除术。使用腰椎侧位X线片,根据考皮拉分类系统对AAC分期进行分类。

结果

2021年8月至2023年12月期间,共有120例患者纳入本研究进行分析,其中82例(68.3%)表现为轻度AAC,38例(31.7%)为中度至重度AAC。使用多变量线性回归模型进行分析显示,AAC合并症与术后临床结局之间存在显著相关性。术后1年,中度至重度AAC患者内镜下腰椎间盘切除术后腿痛的平均变化(5.0分)明显低于轻度AAC患者(p < 0.001)。即使在调整相关混杂因素后,这种差异仍然显著。在术后背痛改善、Oswestry功能障碍指数评分以及36项简短健康调查问卷的身体功能、角色身体和躯体疼痛分量表方面也观察到了类似结果。术后1年,不同严重程度AAC患者的再次手术率或术后新发背痛发生率无显著差异。

结论

接受内镜下腰椎间盘切除术的腰椎间盘突出症患者中,AAC的严重程度与临床结局之间存在显著关联。AAC可作为预测手术结局的预后因素,并指导内镜下腰椎间盘切除术后腰椎间盘突出症患者的管理策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2a75/11393253/76323da3c7a2/40122_2024_633_Fig1_HTML.jpg

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