Department of Internal Medicine, Hospital Universitario Virgen de las Nieves, Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; PA-HELP "Physical Activity for HEaLth Promotion" Research Group, University of Granada, Granada, Spain; Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain.
Department of Education, Faculty of Education Sciences, University of Almería, Almería, Spain; SPORT Research Group (CTS-1024), CIBIS (Centro de Investigación para el Bienestar y la Inclusión Social) Research Center, Univerisity of Almería, Almería, Spain.
Med Clin (Barc). 2024 Oct 18;163(7):327-335. doi: 10.1016/j.medcli.2024.04.023. Epub 2024 Jul 18.
Cardiovascular (CV) diseases are among the main causes of death in systemic lupus erythematosus (SLE). Physical activity (PA) and fitness are potential protective factors against the progression of CV risk factors and atherosclerosis.
To analyze trends over time in PA, sedentary time (ST) and physical fitness and their associations of with traditional and novel markers of CV risk and subclinical atherosclerosis in women with SLE over a 3-year follow-up period.
In this exploratory study, 77 White Hispanic women with SLE (43.3±13.8 years) with mild disease activity were followed after 3 years (n=44). HDL and LDL cholesterol (blood samples), BMI and muscle mass (stadiometer and bioimpedance device), blood pressure (BP), pulse wave velocity (PWV, Mobil-O-Graph® monitor), carotid plaques and intima-media thickness (General Electric Medical Systems, LOGQ-6 model) were assessed. PA and ST were measured using triaxial accelerometers. Physical fitness was assessed with the back-scratch, handgrip strength, 30-s chair stand, and 6-min walk, tests.
After 3 years, LDL-c (estimated mean change [est]=13.77mg/dL) and PWV (0.13m/s) increased while diastolic BP (-2.80mmHG) decreased (all, p<0.05). In mixed models, 6-min walk test was positively associated with HDL-c (est=0.07); back scratch (est=0.33) and chair-stand (est=1.19) tests were positively associated with systolic BP (all, p<0.05). No other trends or associations over time were identified (all, p>0.05).
PA, ST, fitness, and most studied CV risk factors remained stable over time, with only marginal changes in LDL-c, PWV, and diastolic BP. Overall, PA and ST were not longitudinally associated with CV risk factors and subclinical atherosclerosis and contradictory weak associations were found for physical fitness.
心血管疾病是红斑狼疮（SLE）患者主要死亡原因之一。身体活动（PA）和体能是潜在的保护因素，可以防止心血管危险因素和动脉粥样硬化的进展。
分析在 3 年随访期间，SLE 女性 PA、久坐时间（ST）和体能的变化趋势及其与传统和新型心血管风险标志物及亚临床动脉粥样硬化的相关性。
在这项探索性研究中，77 名白种西班牙裔 SLE 女性（43.3±13.8 岁），疾病活动度较轻，在 3 年后（n=44）进行了随访。检测了高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（血液样本）、体重指数（BMI）和肌肉质量（身高计和生物阻抗设备）、血压（BP）、脉搏波速度（PWV，Mobil-O-Graph®监测仪）、颈动脉斑块和内膜中层厚度（通用电气医疗系统，LOGQ-6 型号）。使用三轴加速度计测量 PA 和 ST。使用背抓、握力、30 秒椅站和 6 分钟步行测试评估体能。
3 年后，LDL-c（估计平均变化[est]=13.77mg/dL）和 PWV（0.13m/s）增加，而舒张压（-2.80mmHg）下降（均，p<0.05）。在混合模型中，6 分钟步行测试与 HDL-c 呈正相关（est=0.07）；背抓（est=0.33）和椅站（est=1.19）测试与收缩压呈正相关（均，p<0.05）。没有发现其他随时间变化的趋势或相关性（均，p>0.05）。
PA、ST、体能和大多数研究的心血管危险因素在随访期间保持稳定，只有 LDL-c、PWV 和舒张压有轻微变化。总的来说，PA 和 ST 与心血管危险因素和亚临床动脉粥样硬化没有纵向相关性，而与体能的相关性较弱且相互矛盾。
