Gil-Gutiérrez Rocío, Medina-Martínez Irene, Quesada-Caballero Miguel, de la Hera-Fernández Francisco Javier, Zamora-Pasadas Mónica, Cantarero-Villanueva Irene, Albendín-García Luis, Parola Vítor, Rueda-Medina Blanca, Correa-Rodríguez María
Department of Nursing, Faculty of Health Sciences, University of Granada, 18016 Granada, Spain.
CTS-436 Group, University of Granada, 18016 Granada, Spain.
Nutrients. 2025 Mar 19;17(6):1076. doi: 10.3390/nu17061076.
To analyze the effects of the combination of Extra Virgin Olive Oil (EVOO) supplementation and a health-related lifestyle intervention on disease activity and cardiovascular disease risk factors in Systemic Lupus Erythematosus (SLE).
A total of 38 women with SLE were randomly assigned to EVOO (n = 9) and EVOO combined with multicomponent health promotion and physical exercise program (EVOO + HRLI) (n = 15) or control (CG) (n = 14) groups for 24 weeks. Baseline and post-intervention assessments were performed, collecting data on disease activity, accrual damage, blood biochemical parameters, arterial stiffness parameters, Framingham risk score, anthropometric and body composition measurements, and cardiovascular risk factors.
No changes in disease activity were observed in any group after the intervention. For cardiovascular risk, significant differences were observed in the intervention groups for systolic and mean blood pressure, with greater reductions in the EVOO + HRLI ( = 0.036 vs. < 0.001; = 0.017 vs. < 0.001, respectively). The EVOO group showed significant reductions in BFM and BFP ( = 0.042, = 0.022, respectively). The EVOO+ HRLI group also showed significant reductions in triglycerides ( < 0.001), Aix brachial ( = 0.037), central systolic blood pressure ( < 0.001), central pulse pressure ( = 0.05), body mass index ( = 0.006), body fat mass and skeletal muscle mass ( = 0.039) after the intervention.
Our findings suggest that a multidisciplinary program integrating nutritional interventions, health education, and the promotion of regular physical activity in SLE patients has the potential to significantly improve cardiovascular risk factors and body composition parameters. Thus, integrating this approach into clinical practice alongside usual pharmacological treatments would be beneficial for SLE patients.
NCT05261529.
分析补充特级初榨橄榄油（EVOO）与健康相关生活方式干预相结合对系统性红斑狼疮（SLE）患者疾病活动度和心血管疾病风险因素的影响。
总共38名SLE女性被随机分为EVOO组（n = 9）、EVOO联合多组分健康促进和体育锻炼计划组（EVOO + HRLI）（n = 15）或对照组（CG）（n = 14），干预为期24周。进行基线和干预后评估，收集疾病活动度、累积损伤、血液生化参数、动脉僵硬度参数、弗雷明汉风险评分、人体测量和身体成分测量以及心血管风险因素的数据。
干预后任何组的疾病活动度均未观察到变化。对于心血管风险，干预组在收缩压和平均血压方面观察到显著差异，EVOO + HRLI组的降低幅度更大（分别为P = 0.036 vs. P < 0.001；P = 0.017 vs. P < 0.001）。EVOO组的体脂质量（BFM）和体脂百分比（BFP）显著降低（分别为P = 0.042，P = 0.022）。干预后，EVOO + HRLI组的甘油三酯（P < 0.001）、臂踝脉搏波传导速度（Aix brachial，P = 0.037）、中心收缩压（P < 0.001）、中心脉压（P = 0.05）、体重指数（P = 0.006）、体脂质量和骨骼肌质量（P = 0.039）也显著降低（均为P < 0.001）。
我们的研究结果表明，在SLE患者中整合营养干预、健康教育和促进规律体育活动的多学科计划有可能显著改善心血管风险因素和身体成分参数。因此，将这种方法与常规药物治疗一起纳入临床实践对SLE患者有益。
NCT05261529
