Oral and Maxillofacial Surgeon of Pedro Ernesto University Hospital, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Physics Department, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Clin Implant Dent Relat Res. 2024 Aug;26(4):787-794. doi: 10.1111/cid.13331. Epub 2024 Jun 21.
To evaluate the histomorphometric and computerized microtomographic (Micro-CT) analysis of the regenerated bone tissue from maxillary sinus augmentation surgery, with and without using the collagen membrane on the external osteotomy window.
Twelve patients were selected for this prospective, controlled, and randomized study. The patients were submitted to bilateral maxillary sinus surgery in a split-mouth design. On the test side, the maxillary sinus augmentation procedure included using Geistlich Bio-Oss® and a Geistlich Bio-Gide® collagen membrane covering the lateral osteotomy window. On the control side, only Geistlich Bio-Oss® was used without the presence of the membrane. After 6 months, the surgeries for implant installation were performed. In this surgical phase, specimens of the regenerated tissue were collected for histological and Micro-CT analysis.
In the histomorphometric evaluation, the mean (±SD) percentages of newly formed bone were 43.9% (±11.5) and 40.8% (±8.9) in the test and control groups, respectively. The corresponding values of the Micro-CT analysis were 36.6% (±3.4) and 37.2% (±4.7) in the test and control groups, respectively. There was no statistically significant difference between the test and control groups in the two methods. In addition, there was no statistically significant difference between the mean percentage of biomaterial remaining between the test and control groups. However, the mean percentage of newly formed bone was significantly higher and the mean percentage of remaining biomaterial was significantly lower in the histomorphometric analysis compared to the values obtained through microtomography.
The additional use of collagen membranes in maxillary sinus surgery does not offer advantages in newly formed bone.
评估上颌窦提升术中使用和不使用胶原膜覆盖外部骨切开窗对再生骨组织的组织形态计量学和计算机微断层扫描（Micro-CT）分析。
本前瞻性、对照、随机研究纳入 12 名患者。患者接受双侧上颌窦手术，采用分侧设计。在实验组，上颌窦提升术包括使用 Geistlich Bio-Oss®和 Geistlich Bio-Gide®胶原膜覆盖外侧骨切开窗。在对照组，仅使用 Geistlich Bio-Oss®，不使用膜。6 个月后，进行植入物安装手术。在这个手术阶段，采集再生组织的标本进行组织学和 Micro-CT 分析。
在组织形态计量学评估中，实验组和对照组的新骨形成百分比平均值（±标准差）分别为 43.9%（±11.5）和 40.8%（±8.9）。Micro-CT 分析的相应值分别为实验组和对照组的 36.6%（±3.4）和 37.2%（±4.7）。两种方法在实验组和对照组之间均无统计学差异。此外，实验组和对照组之间剩余生物材料的平均百分比也无统计学差异。然而，与 Micro-CT 分析相比，组织形态计量学分析中新生骨的平均百分比显著更高，而剩余生物材料的平均百分比显著更低。
在上颌窦提升术中额外使用胶原膜并不能为新骨形成带来优势。
