Department of Oral & Maxillofacial Surgery, University of Grande Rio-UNIGRANRIO, Rio de Janeiro 25071-202, Brazil.
Department of Diagnostic and Surgery, Araraquara School of Dentistry, Sao Paulo State University, Sao Paulo 14801-385, Brazil.
Medicina (Kaunas). 2024 Nov 8;60(11):1834. doi: 10.3390/medicina60111834.
: The loss of teeth in the posterior maxillary region often leads to significant alveolar bone resorption and maxillary sinus pneumatization, complicating dental implant placement. Maxillary sinus grafting, typically using autogenous bone, is a common solution. However, autogenous bone grafts require additional surgical procedures, leading to increased morbidity. This study aims to compare the efficacy of two xenografts, Bio-Oss and Cerabone, in promoting new bone formation in maxillary sinus grafting through histomorphometric analysis and micro-computed tomography (micro-CT). : A total of 22 maxillary sinuses (12 right and 10 left) were grafted, with 12 using Cerabone and 10 using Bio-Oss. Six months post-grafting, biopsies were collected for histomorphometric analysis to measure new bone formation, connective tissue, and residual biomaterial. Additionally, micro-CT analysis was performed to assess bone volume fraction, trabecular thickness, number, and separation. : Histomorphometric analysis showed that the Cerabone group had a higher average new bone formation (25.94% ± 10.55) compared to the Bio-Oss group (17.29% ± 4.61), with a statistically significant difference ( = 0.02). Micro-CT analysis revealed that the bone volume fraction in the Cerabone group was significantly higher compared to the Bio-Oss group, with significant differences in trabecular thickness ( = 0.02) but not in trabecular number or separation. : The study demonstrates that both xenografts are effective in promoting new bone formation in maxillary sinus grafting. However, Cerabone showed superior performance in terms of new bone formation and bone volume fraction, suggesting it may be a more effective option for maxillary sinus augmentation procedures.
上颌后牙缺失常导致牙槽骨明显吸收和上颌窦气化，增加牙种植难度。上颌窦提升术通常采用自体骨移植，但需要额外的手术，增加了发病率。本研究旨在通过组织形态计量学分析和微计算机断层扫描（micro-CT）比较两种异种移植物（Bio-Oss 和 Cerabone）在上颌窦提升中促进新骨形成的疗效。
共 22 例上颌窦（12 例右侧，10 例左侧）接受了移植，Cerabone 组 12 例，Bio-Oss 组 10 例。移植后 6 个月，取活检进行组织形态计量学分析，以测量新骨形成、结缔组织和残留生物材料。此外，还进行了 micro-CT 分析，以评估骨体积分数、小梁厚度、数量和分离度。
组织形态计量学分析显示，Cerabone 组的平均新骨形成（25.94%±10.55）高于 Bio-Oss 组（17.29%±4.61），差异有统计学意义（=0.02）。micro-CT 分析显示，Cerabone 组的骨体积分数明显高于 Bio-Oss 组，小梁厚度差异有统计学意义（=0.02），但小梁数量和分离度差异无统计学意义。
该研究表明，两种异种移植物在上颌窦提升中均能有效促进新骨形成。然而，Cerabone 组在新骨形成和骨体积分数方面表现更优，表明其可能是上颌窦增强术的更有效选择。
