Hu Yang, Cao Chi, Zhang Lin, Yang Wensheng
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, China.
Engineering Research Center for Nanomaterials, Henan University, Kaifeng 475000, China.
Langmuir. 2024 Jul 20. doi: 10.1021/acs.langmuir.4c02025.
This study investigates the utilization of choline hydroxide as a cocatalyst in the Stöber method to synthesize silica particles with controlled microstructure. Under low ammonia concentration, we add a robust organic base choline hydroxide and systematically explore the influence of choline hydroxide concentration on the hydrolysis and condensation equilibrium of tetraethyl orthosilicate (TEOS). Through the rational control of the water content, we significantly enhance both the size range and polydispersity of the resulting silica particles. Taking advantage of the regulated microstructure induced by controlled hydrolysis and condensation catalyzed by choline hydroxide, we achieved silica particles with hollow structures through hot water etching, exhibiting significantly enhanced surface area. These findings demonstrate the versatility of choline hydroxide as a cocatalyst in tailoring the microstructure of silica particles. In addition, due to its reducing ability and biocompatibility, which are not shared by other reported catalysts, the use of choline hydroxide opens up opportunities for applications in catalysis, sensing, and drug delivery.
本研究考察了氢氧化胆碱作为共催化剂在Stöber法中用于合成具有可控微观结构的二氧化硅颗粒的情况。在低氨浓度下，我们添加了一种强有机碱氢氧化胆碱，并系统地探究了氢氧化胆碱浓度对正硅酸乙酯（TEOS）水解和缩合平衡的影响。通过合理控制含水量，我们显著扩大了所得二氧化硅颗粒的尺寸范围并提高了其多分散性。利用由氢氧化胆碱催化的可控水解和缩合所诱导的微观结构调控，我们通过热水蚀刻制备出了具有中空结构的二氧化硅颗粒，其表面积显著增大。这些发现证明了氢氧化胆碱作为共催化剂在定制二氧化硅颗粒微观结构方面的多功能性。此外，由于其具有其他已报道催化剂所不具备的还原能力和生物相容性，氢氧化胆碱的使用为催化、传感和药物递送等应用开辟了机会。
