Vörös-Horváth Barbara, Salem Ala', Kovács Barna, Széchenyi Aleksandar, Pál Szilárd
Institute of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, University of Pécs, H-7624 Pécs, Hungary.
Quality Systems Department 3, Egis Pharmaceuticals PLC, H-1475 Budapest, Hungary.
Nanomaterials (Basel). 2024 Sep 27;14(19):1561. doi: 10.3390/nano14191561.
This study presents a reproducible and scalable method for synthesizing silica nanoparticles (SNPs) with controlled sizes below 200 nm, achieved by systematically varying three key reaction parameters: ammonium hydroxide concentration, water concentration, and temperature. SNPs with high monodispersity and controlled dimensions were produced by optimizing these factors. The results indicated a direct correlation between ammonium hydroxide concentration and particle size, while higher temperatures resulted in smaller particles with increased polydispersity. Water concentration also influenced particle size, with a quadratic relationship observed. This method provides a robust approach for tailoring SNP sizes, with significant implications for biomedical applications, particularly in drug delivery and diagnostics. Using eco-friendly solvents such as ethanol further enhances the sustainability and cost-effectiveness of the process.
本研究提出了一种可重复且可扩展的方法，用于合成尺寸可控且小于200纳米的二氧化硅纳米颗粒（SNP），该方法通过系统地改变三个关键反应参数来实现：氢氧化铵浓度、水浓度和温度。通过优化这些因素，制备出了具有高单分散性和可控尺寸的SNP。结果表明，氢氧化铵浓度与颗粒尺寸之间存在直接关联，而较高的温度会导致颗粒尺寸减小且多分散性增加。水浓度也会影响颗粒尺寸，呈现出二次关系。该方法为定制SNP尺寸提供了一种可靠的途径，对生物医学应用具有重要意义，特别是在药物递送和诊断方面。使用乙醇等环保型溶剂进一步提高了该过程的可持续性和成本效益。
