Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, China; Key Laboratory of Psychosomatic Medicine, Chinese Academy of Medical Sciences, Chengdu 610072, China; Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Program in Mental Health, Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Cognitive Impairment and Dementia Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Cognitive Fitness and Biopsychological Technology Research Unit, Faculty of Medicine Chulalongkorn University, Bangkok 10330, Thailand; Department of Psychiatry, Medical University of Plovdiv, Plovdiv, Bulgaria; Research Institute, Medical University of Plovdiv, Plovdiv, Bulgaria; Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea; Research and Innovation Program for the Development of MU - PLOVDIV-(SRIPD-MUP)", Creation of a Network of Research Higher Schools, National Plan for Recovery and Sustainability, European Union - NextGenerationEU; Center of Excellence for Maximizing Children's Developmental Potential, Department of Pediatric, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Program in Mental Health, Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Center of Excellence for Maximizing Children's Developmental Potential, Department of Pediatric, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Psychiatry Res. 2024 Sep;339:116085. doi: 10.1016/j.psychres.2024.116085. Epub 2024 Jul 15.
In this study, we aimed to investigate the associations between the recurrence of illness (ROI) and biomarkers related to an activated immune network, immune-linked neurotoxicity (INT), and a combined INT and atherogenicity index (METAMMUNE). The study involved 67 healthy controls and 66 outpatient MDD (OMDD) participants. We utilized a Multiplex method to measure 48 cytokines and examined INT and METAMMUNE composite scores in association with different ROI indices. Our findings revealed that a ROI index was successfully created by extracting a validated principal component, from the physician-rated or self-declared number of depressive episodes, the frequency of lifetime suicidal ideation and attempts. ROI was significantly associated with INT and METAMMUNE indices, neuroticism, lifetime and current suicidal behaviors, and the phenome. Our analysis also revealed that a significant portion of the variance in the OMDD phenome, which includes current suicidal behaviors, anxiety, and depression, can be accounted for by the regression on INT, ROI, and emotional neglect and abuse. A validated latent construct was successfully extracted from the three ROI components, INT and METAMMUNE indices. The results indicate that increasing ROI indicates heightened immune-metabolic abnormalities, increased risk of suicidal behaviors, and elevated severity of lifetime and current phenome features.
在这项研究中，我们旨在探讨与免疫网络激活相关的生物标志物、免疫相关神经毒性（INT）和 INT 与动脉粥样硬化指数的综合指标（METAMMUNE）与疾病复发（ROI）之间的关联。研究共纳入 67 名健康对照者和 66 名门诊 MDD（OMDD）参与者。我们使用多重方法测量了 48 种细胞因子，并检测了与不同 ROI 指数相关的 INT 和 METAMMUNE 综合评分。研究结果表明，通过提取医生评分或自我报告的抑郁发作次数、终生自杀意念和自杀尝试频率的验证性主成分，可以成功创建 ROI 指数。ROI 与 INT 和 METAMMUNE 指数、神经质、终生和当前自杀行为以及表型显著相关。我们的分析还表明，OMDD 表型中当前自杀行为、焦虑和抑郁等当前和终生的许多表型特征可以通过 INT、ROI、情感忽视和虐待的回归来解释。从三个 ROI 成分、INT 和 METAMMUNE 指数中成功提取了一个经过验证的潜在结构。结果表明，ROI 的增加表明免疫代谢异常加剧、自杀行为风险增加以及终生和当前表型特征严重程度升高。
