Doughnut-shaped bimetallic Cu-Zn-MOF with peroxidase-like activity for colorimetric detection of glucose and antibacterial applications.

Metal-organic frameworks (MOFs), especially bimetallic MOFs, have attracted widespread attention for simulating the structure and function of natural enzymes. In this study, different morphologies of bimetallic Cu-Zn-MOF with different peroxidase (POD)-like activities were prepared by simply controlling the molar ratio of Cu and Zn. Among them, the doughnut-shaped Cu-Zn-MOF exhibited the largest POD-like activity. Cu-Zn-MOF was combined with glucose oxidase to construct a sensitive and selective glucose colorimetric biosensor with a linear detection range of 10-300 μM and a detection limit of 7.1 μm. Furthermore, Cu-Zn-MOF can efficiently convert hydrogen peroxide (HO) into hydroxyl radicals that effectively kill both gram-negative and gram-positive bacteria at low HO level. The results of this study may promote the synthesis of bimetallic MOFs and broaden their applications in the biomedical field.