Hu Xudong, Li Yueshuo, Cao Ya, Shi Feng, Shang Li
Key Laboratory of Carcinogenesis and Cancer Invasion of Chinese Ministry of Education, XiangYa Hospital, Central South University, Changsha 410078, China; Department of Pathology, National Clinical Research Center for Geriatric Disorders/ XiangYa Hospital, Central South University, Changsha 410078, China; Key Laboratory of Carcinogenesis of National Health Commission, Cancer Research Institute and School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha 410078, China.
Key Laboratory of Carcinogenesis and Cancer Invasion of Chinese Ministry of Education, XiangYa Hospital, Central South University, Changsha 410078, China; Key Laboratory of Carcinogenesis of National Health Commission, Cancer Research Institute and School of Basic Medical Science, Xiangya School of Medicine, Central South University, Changsha 410078, China.
Biochim Biophys Acta Rev Cancer. 2024 Sep;1879(5):189156. doi: 10.1016/j.bbcan.2024.189156. Epub 2024 Jul 18.
As a free radical and endogenous effector molecule, mammalian endogenous nitric oxide (NO) is mainly derived from nitric oxide synthase (NOS) via L-arginine. NO participates in normal physiological reactions and provides immune responses to prevent the invasion of foreign bacteria. However, NO also has complex and contradictory biological effects. Abnormal NO signaling is involved in the progression of many diseases, such as cancer. In the past decades, cancer research has been closely linked with NOS/ NO, and many tumors with poor prognosis are associated with high expression of NOS. In this review, we give a overview of the biological effects of NOS/ NO. Then we focus on the oncogenic role of iNOS/ NO in HPV, HBV, EBV and H. pylori related tumors. In fact, there is growing evidence that iNOS could be used as a potential therapeutic target in cancer therapy. We emphasize that the pro-tumor effect of NOS/ NO is greater than the anti-tumor effect.
作为一种自由基和内源性效应分子，哺乳动物内源性一氧化氮（NO）主要通过L-精氨酸由一氧化氮合酶（NOS）产生。NO参与正常生理反应并提供免疫应答以防止外来细菌的入侵。然而，NO也具有复杂且矛盾的生物学效应。异常的NO信号传导参与许多疾病的进展，如癌症。在过去几十年中，癌症研究与NOS/NO密切相关，许多预后不良的肿瘤与NOS的高表达有关。在这篇综述中，我们概述了NOS/NO的生物学效应。然后我们重点关注诱导型NOS/NO在人乳头瘤病毒（HPV）、乙型肝炎病毒（HBV）、EB病毒（EBV）和幽门螺杆菌相关肿瘤中的致癌作用。事实上，越来越多的证据表明诱导型NOS可作为癌症治疗中的潜在治疗靶点。我们强调，NOS/NO的促肿瘤作用大于抗肿瘤作用。
