Xia Dan, Guo Ying, Xu Ruodan, Li Ning
Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology, School of Materials Science and Engineering, Hebei University of Technology, Tianjin, 300130, China.
Department of Biobmedical Engineering and Technology, Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
J Nanobiotechnology. 2025 Jan 29;23(1):53. doi: 10.1186/s12951-025-03135-1.
The challenges associated with prolonged healing or non-healing of chronic diabetic wounds contribute significantly to the increased incidence of lower limb amputation. A pivotal factor in the impediment of healing is the reduced production of endogenous nitric oxide (NO) due to the hyperglycemic microenvironment typical of chronic diabetes. While both endogenous and exogenous NO have been shown to promote the healing process of diabetic wounds, the direct application of NO in wound management is limited due to its gaseous nature and the risk of explosive release. This review summarizes recent advances of nanodressings incorporating NO donors in the treatment of diabetic wounds, detailing the specific conditions under which these nanodressings facilitate NO release, with a focus on the beneficial effects of NO, strategies for its supplementation, and the challenges encountered in the clinical translation of NO donors as a clinically viable nanomedicine in the context of improving diabetic wound healing.
慢性糖尿病伤口长期不愈合或愈合缓慢所带来的挑战，是导致下肢截肢发生率增加的重要因素。愈合受阻的一个关键因素是，慢性糖尿病典型的高血糖微环境会使内源性一氧化氮（NO）生成减少。虽然内源性和外源性NO均已被证明可促进糖尿病伤口的愈合过程，但由于NO的气态性质以及爆炸释放的风险，其在伤口处理中的直接应用受到限制。本综述总结了含NO供体的纳米敷料在糖尿病伤口治疗中的最新进展，详细阐述了这些纳米敷料促进NO释放的具体条件，重点关注NO的有益作用、补充策略，以及在改善糖尿病伤口愈合的背景下，将NO供体作为一种临床可行的纳米药物进行临床转化时所遇到的挑战。
