Xu Jia, Liu Yilin, Wang Qing, Tao Xiangzhang, Ni Shengyang, Zhang Weigang, Yu Lei, Pan Yi, Wang Yi
Jiangsu Key Laboratory of Advanced Organic Materials, State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China.
Nat Commun. 2024 Jul 20;15(1):6116. doi: 10.1038/s41467-024-50596-3.
Alkylamine structures represent one of the most functional and widely used in organic synthesis and drug design. However, the general methods for the functionalization of the shielded and deshielded alkyl radicals remain elusive. Here, we report a general deoxygenative amination protocol using alcohol-derived carbazates and nitrobenzene under electrochemical conditions. A range of primary, secondary, and tertiary alkylamines are obtained. This practical procedure can be scaled up through electrochemical continuous flow technique.
烷基胺结构是有机合成和药物设计中功能最多且应用最广泛的结构之一。然而，关于被保护和去保护的烷基自由基功能化的通用方法仍然未知。在此，我们报道了一种在电化学条件下使用醇衍生的氨基甲酸酯和硝基苯的通用脱氧胺化方法。可获得一系列伯、仲和叔烷基胺。这一实用方法可通过电化学连续流动技术进行放大。
