Chiang Che-Yu, Lo Su-Chen, Beckstead Jason W, Yang Chiu-Yueh
Department of Family and Community Medicine, Cathay General Hospital, Taipei, Taiwan.
National Yang Ming Chiao Tung University, Taipei, Taiwan.
Soc Psychiatry Psychiatr Epidemiol. 2025 Feb;60(2):427-440. doi: 10.1007/s00127-024-02729-8. Epub 2024 Jul 20.
To investigate the association between lifestyle and atypical antipsychotic drug use in patients with schizophrenia and the risk of constipation and to assess the impact of anxiety and depressive symptoms on constipation risk.
Cross-sectional convenience sampling was employed, and 271 participants aged 20-65 were enrolled. Data were collected via a structured questionnaire comprising participants' demographic data, medication information, dietary behavior assessment, and the Baecke Physical Activity Questionnaire, Beck Depression Inventory-II, and Beck Anxiety Inventory. IBM SPSS 24.0 with multivariate logistic regression was used for data analysis. We performed a subgroup analysis of anticholinergic drugs via multivariate logistic regression.
In total, 180 participants had functional constipation; risk factors included female sex, anxiety symptoms, depressive symptoms, and quetiapine and aripiprazole use. Patients who drank more than 3,000 cc of water daily or used risperidone were less likely to have functional constipation. Depressive and anxiety symptoms were risk factors even after adjusting for sex, use of anticholinergics and laxatives, consuming two servings of fruit, consuming three servings of vegetables, consuming more than 3,000 cc of water daily, physical activity, medical comorbidity, chlorpromazine equivalent dose, and atypical antipsychotic use. Similar associations were found for two affective symptoms and functional constipation in the subgroup analysis of anticholinergic drugs.
The prevalence of functional constipation in patients with schizophrenia was 66.4%. The risk factors included female sex, anticholinergics, aripiprazole, quetiapine, and depressive and anxiety symptoms. Risperidone users and those who drank 3000 cc of water daily were less likely to have constipation.
探讨精神分裂症患者的生活方式与非典型抗精神病药物使用之间的关联以及便秘风险，并评估焦虑和抑郁症状对便秘风险的影响。
采用横断面便利抽样法，纳入271名年龄在20 - 65岁的参与者。通过一份结构化问卷收集数据，该问卷包括参与者的人口统计学数据、用药信息、饮食行为评估以及贝克体力活动问卷、贝克抑郁量表第二版和贝克焦虑量表。使用IBM SPSS 24.0进行多因素逻辑回归分析。我们通过多因素逻辑回归对抗胆碱能药物进行了亚组分析。
共有180名参与者存在功能性便秘；危险因素包括女性、焦虑症状、抑郁症状以及使用喹硫平和阿立哌唑。每天饮水超过3000毫升或使用利培酮的患者发生功能性便秘的可能性较小。即使在调整了性别、抗胆碱能药物和泻药的使用、食用两份水果、食用三份蔬菜、每天饮水超过3000毫升、体力活动、合并疾病、氯丙嗪等效剂量和非典型抗精神病药物使用等因素后，抑郁和焦虑症状仍是危险因素。在抗胆碱能药物的亚组分析中，两种情感症状与功能性便秘之间也发现了类似的关联。
精神分裂症患者中功能性便秘的患病率为66.4%。危险因素包括女性、抗胆碱能药物、阿立哌唑、喹硫平以及抑郁和焦虑症状。使用利培酮的患者和每天饮水3000毫升的患者便秘的可能性较小。
