Zhong Han-Zhi, Mo Jing, Li Yan-Xin, Li Mao-Ya, Wei Shao-Bin
School of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Department of Gynecology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Front Pharmacol. 2024 Jul 3;15:1426972. doi: 10.3389/fphar.2024.1426972. eCollection 2024.
This study evaluates the research developments concerning Rehmanniae Radix in ovarian hypofunction diseases. It explores the processing methods of Rehmanniae Radix, the variations in its compounds before and after processing, the mechanism of Rehmanniae Radix and its active compounds in improving ovarian function, and the advancements in clinical applications of traditional Chinese medicine (TCM) compound that include Rehmanniae Radix.
Comprehensive literature search was conducted using databases such as China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database, National Science and Technology Library, the Pharmacopoeia of the People's Republic of China, Pubmed, and the Web of Science Database. The search utilized the following Medical Subject Headings (MeSH) and keywords: "Rehmanniae Radix," "Drying Rehmannia Root," "Rehmannia glutinosa," "Rehmanniae Radix Praeparata," "Traditional Chinese Medicine Processing," "Pharmacological Effects," "Ovarian Aging," "Diminished ovarian reserve," "Premature ovarian insufficiency," "Premature Ovarian Failure," "Ovarian hypofunction diseases".
The ancient Chinese medical books document various processing techniques for Rehmanniae Radix. Contemporary research has identified changes in its compounds processing and the resultant diverse therapeutic effects. When processed into Rehmanniae Radix Praeparata, it is noted for its ability to invigorate the kidney. TCM compound containing Rehmanniae Radix is frequently used to treat ovarian hypofunction diseases, demonstrating significant clinical effectiveness. The key changes in its compounds processing include cyclic dilute ether terpene glycosides, phenylethanol glycosides, sugars, and 5-hydroxymethylfurfural. Its pharmacological action is primarily linked to the improvement of granulosa cell proliferation, antioxidative and anti-aging properties, and modulation of the immune and inflammatory microenvironment. Furthermore, Rehmanniae Radix also offers therapeutic benefits for cardiovascular and cerebrovascular diseases, osteoporosis and cognitive dysfunction caused by low estrogen levels. Thereby Rehmanniae Radix mitigates both the short-term and long-term health risks associated with ovarian hypofunction diseases.
Processed Rehmanniae Radix has shown potential to improve ovarian function, and its compound prescriptions have a definite effect on ovarian dysfunction diseases. Therefore Rehmanniae Radix was garnering interest for both basic and clinical research, with promising application prospects as a future therapeutic agent for ovarian hypofunction diseases. However, further studies on its toxicology and the design of standardized clinical trials are necessary to fully establish its efficacy and safety.
本研究评估熟地黄在卵巢功能减退疾病方面的研究进展。探讨熟地黄的炮制方法、炮制前后化合物的变化、熟地黄及其活性成分改善卵巢功能的机制，以及含熟地黄的中药复方在临床应用方面的进展。
使用中国知网（CNKI）、中国科技期刊数据库、国家科技图书文献中心、《中华人民共和国药典》、PubMed和Web of Science数据库等进行全面的文献检索。检索使用了以下医学主题词（MeSH）和关键词：“熟地黄”、“生地黄”、“地黄”、“熟地黄”、“中药炮制”、“药理作用”、“卵巢衰老”、“卵巢储备功能减退”、“卵巢早衰”、“卵巢功能不全”、“卵巢功能减退疾病”。
中国古代医书记载了熟地黄的多种炮制技术。当代研究已确定其化合物在炮制过程中的变化以及由此产生的不同治疗效果。制成熟地黄后，其以补肾功效著称。含熟地黄的中药复方常用于治疗卵巢功能减退疾病，显示出显著的临床疗效。其化合物加工的关键变化包括环烯醚萜苷、苯乙醇苷、糖类和5-羟甲基糠醛。其药理作用主要与促进颗粒细胞增殖、抗氧化和抗衰老特性以及调节免疫和炎症微环境有关。此外，熟地黄还对心血管和脑血管疾病、雌激素水平低引起的骨质疏松和认知功能障碍具有治疗作用。从而减轻了与卵巢功能减退疾病相关的短期和长期健康风险。
炮制后的熟地黄已显示出改善卵巢功能的潜力，其复方制剂对卵巢功能障碍疾病有确切疗效。因此，熟地黄在基础和临床研究方面都备受关注，作为未来治疗卵巢功能减退疾病的药物具有广阔的应用前景。然而，有必要对其毒理学和标准化临床试验设计进行进一步研究，以充分确定其疗效和安全性。
