Agoons Dayawa D, Agoons Batakeh B, Emmanuel Kelechi E, Matawalle Firdausi A, Cunningham Jessica M
Department of Medicine, UPMC Pinnacle, Harrisburg, PA, USA.
Department of Medicine, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon.
Am J Med Open. 2021 Sep 16;1-6:100002. doi: 10.1016/j.ajmo.2021.100002. eCollection 2021.
The popularity of electronic cigarette (e-cigarette) use continues to rise in the United States. While conventional cigarette smoking is an established risk factor for osteoporosis and osteoporotic fracture, the effects of e-cigarette use on bone health are unknown. We aimed to examine the association between e-cigarette use and fragility fractures.
We pooled 2017-2018 data from the National Health and Nutrition Examination Survey (NHANES). We included men and women with complete information on key variables. E-cigarette use was categorized as either never or ever users. Ever users were further classified as former and current users. Fragility fracture was defined as a composite of self-reported fracture of the hip, spine or wrist which resulted from minimal trauma such as a fall from standing height or less.
Of 5569 participants, there were 4519 (81.2%) never e-cigarette users, 1050 (18.8%) ever e-cigarette users, and 444 (8.0%) with self-reported fragility fracture. In adjusted models, ever e-cigarette users had a 46% higher prevalence of self-reported fragility fractures compared to never users (aPR: 1.46, 95% CI: 1.12, 1.89). We also observed a higher prevalence of fragility fractures among former and current e-cigarette users compared to never users (aPR: 1.89, 95% CI: 1.44, 2.48 and aPR: 1.77, 95% CI: 1.04, 3.02 respectively).
E-cigarette use was associated with a higher prevalence of self-reported fragility fracture. These findings suggest that e-cigarette use may be harmful to bone health. These data highlight the critical need for longitudinal studies exploring the potential effect(s) of e-cigarette use on bone health.
在美国，电子烟的使用普及率持续上升。虽然传统吸烟是骨质疏松症和骨质疏松性骨折的既定风险因素，但电子烟使用对骨骼健康的影响尚不清楚。我们旨在研究电子烟使用与脆性骨折之间的关联。
我们汇总了2017 - 2018年国家健康与营养检查调查（NHANES）的数据。我们纳入了关键变量信息完整的男性和女性。电子烟使用分为从不使用者和曾经使用者。曾经使用者进一步分为既往使用者和当前使用者。脆性骨折定义为自我报告的髋部、脊柱或腕部骨折，这些骨折由诸如从站立高度或更低高度跌倒等轻微创伤导致。
在5569名参与者中，有4519名（81.2%）从不使用电子烟者，1050名（18.8%）曾经使用电子烟者，以及444名（8.0%）自我报告有脆性骨折者。在调整模型中，曾经使用电子烟者自我报告的脆性骨折患病率比从不使用者高46%（调整后患病率比：1.46，95%置信区间：1.12，1.89）。我们还观察到，与从不使用者相比，既往和当前电子烟使用者的脆性骨折患病率更高（调整后患病率比分别为：1.89，95%置信区间：1.44，2.48和1.77，95%置信区间：1.04，3.02）。
电子烟使用与自我报告的脆性骨折患病率较高相关。这些发现表明，电子烟使用可能对骨骼健康有害。这些数据凸显了开展纵向研究以探索电子烟使用对骨骼健康潜在影响的迫切需求。
