地尔硫䓬与阿替洛尔治疗心绞痛的比较。
A comparison of diltiazem and atenolol in angina.
作者信息
Wheatley D
出版信息
Postgrad Med J. 1985 Sep;61(719):785-9. doi: 10.1136/pgmj.61.719.785.
Abstract
Diltiazem was compared to atenolol in a double-blind trial involving 78 patients suffering from coronary heart disease. Following a 2 week control period, patients were randomly allocated to 6 weeks treatment with one or the other drug. The patients themselves made daily records of anginal attacks, trinitrate requirements, well-being and exercise tolerance. With both drugs there were highly significant reductions in the anginal attack rate and trinitrate requirements, and significant improvement on the other measures. However, there were no significant between drug differences. The incidence of side effects with diltiazem was very low and no patient had to omit treatment for this reason, although three patients did so on atenolol.
摘要
在一项涉及78名冠心病患者的双盲试验中，将地尔硫䓬与阿替洛尔进行了比较。在为期2周的对照期之后，患者被随机分配接受其中一种药物为期6周的治疗。患者自行每天记录心绞痛发作情况、硝酸酯类药物的使用需求、健康状况和运动耐量。两种药物治疗后，心绞痛发作率和硝酸酯类药物的使用需求均显著降低，其他各项指标也有显著改善。然而，两种药物之间没有显著差异。地尔硫䓬的副作用发生率非常低，没有患者因此而不得不中断治疗，尽管有3名使用阿替洛尔的患者不得不中断治疗。
相似文献
1
A comparison of diltiazem and atenolol in angina.地尔硫䓬与阿替洛尔治疗心绞痛的比较。
Postgrad Med J. 1985 Sep;61(719):785-9. doi: 10.1136/pgmj.61.719.785.
2
Effects of ranolazine with atenolol, amlodipine, or diltiazem on exercise tolerance and angina frequency in patients with severe chronic angina: a randomized controlled trial.雷诺嗪联合阿替洛尔、氨氯地平或地尔硫䓬对严重慢性心绞痛患者运动耐量和心绞痛发作频率的影响：一项随机对照试验。
JAMA. 2004 Jan 21;291(3):309-16. doi: 10.1001/jama.291.3.309.
3
Comparison of diltiazem and nifedipine for both angina pectoris and systemic hypertension.地尔硫䓬与硝苯地平治疗心绞痛和全身性高血压的比较。
Am J Cardiol. 1985 Dec 6;56(16):41H-46H. doi: 10.1016/0002-9149(85)90542-9.
4
Efficacy of diltiazem in angina on effort: a multicenter trial.地尔硫䓬对劳力性心绞痛的疗效：一项多中心试验。
Am J Cardiol. 1982 Feb 18;49(3):567-72. doi: 10.1016/s0002-9149(82)80013-1.
5
Long-term monotherapy of angina pectoris with diltiazem.地尔硫䓬长期单药治疗心绞痛。
Aust N Z J Med. 1985 Apr;15(2):221-5. doi: 10.1111/j.1445-5994.1985.tb04011.x.
6
Amlodipine versus diltiazem as additional antianginal treatment to atenolol. Centralised European Studies in Angina Research (CESAR) Investigators.氨氯地平与地尔硫䓬作为阿替洛尔的附加抗心绞痛治疗。欧洲心绞痛研究集中研究（CESAR）调查人员。
Am J Cardiol. 1998 Jan 15;81(2):133-6. doi: 10.1016/s0002-9149(97)00893-x.
7
Exercise capacity and hemodynamics in persons aged 20 to 50 years with systemic hypertension treated with diltiazem and atenolol.
Am J Cardiol. 1987 Oct 1;60(10):832-5. doi: 10.1016/0002-9149(87)91032-0.
8
9
Comparison of atenolol with propranolol in the treatment of angina pectoris with special reference to once daily administration of atenolol.阿替洛尔与普萘洛尔治疗心绞痛的比较，特别提及阿替洛尔的每日一次给药
Br Heart J. 1978 Sep;40(9):998-1004. doi: 10.1136/hrt.40.9.998.
10
Safety and efficacy of diltiazem hydrochloride for the treatment of stable angina pectoris: report of a cooperative clinical trial.盐酸地尔硫䓬治疗稳定型心绞痛的安全性和有效性：一项合作临床试验报告。
Am J Cardiol. 1982 Feb 18;49(3):560-6. doi: 10.1016/s0002-9149(82)80012-x.
引用本文的文献
1
Antihypertensive efficacy of twice daily controlled release diltiazem using 24 hour intra-arterial blood pressure monitoring.使用24小时动脉内血压监测评估每日两次控释地尔硫䓬的降压疗效。
Eur J Clin Pharmacol. 1994;46(5):427-30. doi: 10.1007/BF00191905.
2
Diltiazem. A reappraisal of its pharmacological properties and therapeutic use.地尔硫䓬。对其药理特性和治疗用途的重新评估。
Drugs. 1990 May;39(5):757-806. doi: 10.2165/00003495-199039050-00009.
3
Atenolol. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disorders.阿替洛尔：对其药理特性及在心血管疾病治疗应用的重新评估
Drugs. 1991 Sep;42(3):468-510. doi: 10.2165/00003495-199142030-00007.
本文引用的文献
1
Calcium antagonists.钙拮抗剂
Eur Heart J. 1980 Jun;1(3):225-37. doi: 10.1093/oxfordjournals.eurheartj.a061123.
2
Divergent effects of diltiazem in patients with exertional angina.地尔硫䓬对劳力性心绞痛患者的不同影响。
Am J Cardiol. 1982 Feb 18;49(3):538-46. doi: 10.1016/s0002-9149(82)80009-x.
3
Diltiazem: a review of its clinical efficacy and use.地尔硫䓬：临床疗效与应用综述
Drug Intell Clin Pharm. 1982 May;16(5):371-9. doi: 10.1177/106002808201600503.
4
Efficacy of diltiazem in angina on effort: a multicenter trial.地尔硫䓬对劳力性心绞痛的疗效：一项多中心试验。
Am J Cardiol. 1982 Feb 18;49(3):567-72. doi: 10.1016/s0002-9149(82)80013-1.
5
Safety and efficacy of diltiazem hydrochloride for the treatment of stable angina pectoris: report of a cooperative clinical trial.盐酸地尔硫䓬治疗稳定型心绞痛的安全性和有效性：一项合作临床试验报告。
Am J Cardiol. 1982 Feb 18;49(3):560-6. doi: 10.1016/s0002-9149(82)80012-x.
6
Short- and long-term responses to diltiazem in patients with variant angina.
Am J Cardiol. 1982 Feb 18;49(3):554-9. doi: 10.1016/s0002-9149(82)80011-8.
7
Calcium channel blocking agents in the treatment of cardiovascular disorders. Part II: Hemodynamic effects and clinical applications.钙通道阻滞剂在心血管疾病治疗中的应用。第二部分：血流动力学效应及临床应用。
Ann Intern Med. 1980 Dec;93(6):886-904. doi: 10.7326/0003-4819-93-6-886.
8
The use of diltiazem hydrochloride in cardiovascular disorders.
Pharmacotherapy. 1982 May-Jun;2(3):121-33. doi: 10.1002/j.1875-9114.1982.tb04518.x.
9
Effects of diltiazem on cardiovascular responses during exercise in systemic hypertension and comparison with propranolol.地尔硫䓬对系统性高血压患者运动期间心血管反应的影响及其与普萘洛尔的比较。
Am J Cardiol. 1983 Nov 1;52(8):1023-7. doi: 10.1016/0002-9149(83)90524-6.
10
Diltiazem in the treatment of mild or moderate essential hypertension. Comparison with metoprolol in a crossover double-blind trial.地尔硫䓬治疗轻度或中度原发性高血压。在交叉双盲试验中与美托洛尔的比较。
J Clin Pharmacol. 1984 May-Jun;24(5-6):218-27. doi: 10.1002/j.1552-4604.1984.tb02777.x.
Zotero 插件