State Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing University of Chemical Technology, Beijing, 100029, China.
Max Planck Institute for Polymer Research, Ackermannweg 10, D-55128, Mainz, Germany.
Small. 2024 Nov;20(45):e2403284. doi: 10.1002/smll.202403284. Epub 2024 Jul 22.
Thrombus causes a serious condition characterized by the formation of blood clots in blood vessels or heart, potentially leading to life-threatening emergencies. Photothermal therapy (PTT) serves as a treatment for thrombosis that provides noninvasive thrombus dissolution and fewer bleeding side effects. However, the high temperatures generated by PTT can exacerbate vascular inflammation and promote thrombus recurrence. In this study, a photothermal hydrogen sulfide (HS) nanogenerator (PSA@ADT-OH) is constructed using a perylene-cored photothermal agent (PSA) coassembled with a HS donor ADT-OH. The system PSA@ADT-OH demonstrates outstanding targeting and accumulation efficiency against blood flow shear forces. It also provides sustained HS release at thrombus sites, contributing to antiplatelet aggregation, reactive oxygen species clearance, and vascular healing. This approach opens up new possibilities for advanced thrombus treatment.
血栓导致一种严重的病症，其特征是血管或心脏中形成血块，可能导致危及生命的紧急情况。光热疗法（PTT）是一种治疗血栓的方法，可提供非侵入性的血栓溶解和较少的出血副作用。然而，PTT 产生的高温会加剧血管炎症并促进血栓复发。在这项研究中，构建了一种基于光热硫化氢（HS）纳米发电机（PSA@ADT-OH），它使用了一种以苝为核的光热试剂（PSA）与 HS 供体 ADT-OH 共聚组装而成。该系统 PSA@ADT-OH 对血流剪切力具有出色的靶向和积累效率。它还在血栓部位持续释放 HS，有助于抗血小板聚集、清除活性氧物质和血管愈合。这种方法为先进的血栓治疗开辟了新的可能性。
