Jörgensen T M, Nörgaard J P, Mortensen J, Djurhuus J C
Scand J Urol Nephrol. 1985;19(2):113-7. doi: 10.3109/00365598509180237.
In a study of the dynamic function of the urinary tract in infravesically obstructed pigs with vesicoureteric reflux, 5 pigs with 6 refluxing ureters evidenced urinary tract infection after 8 and 10 weeks of obstruction. Examination showed that the median ureteric baseline activity had decreased to 0.0 A.P./min (action potentials/min). During bladder filling, no increase in activity was seen, although there was pressure equilibration between the bladder and the renal pelvis, when the reflux producing bladder pressure was reached. Only a few episodes of retrograde activity were recorded during the bladder filling. 46% of the ureteric contractions were incomplete and stopped in the mid-third of ureter. The study showed the severe, irreversible impairment of ureteric function when subjected to not only reflux and obstruction but also infection.
在一项对伴有膀胱输尿管反流的膀胱下梗阻猪的尿路动态功能的研究中，5头猪的6条反流输尿管在梗阻8周和10周后出现了尿路感染。检查显示输尿管中位基线活动已降至0.0次动作电位/分钟（动作电位/分钟）。在膀胱充盈期间，尽管当达到产生反流的膀胱压力时膀胱与肾盂之间压力达到平衡，但未观察到活动增加。在膀胱充盈期间仅记录到少数几次逆行活动。46%的输尿管收缩不完全并在输尿管中三分之一处停止。该研究表明，输尿管不仅受到反流和梗阻，还受到感染时，其功能会受到严重的、不可逆的损害。
