Jörgensen T M
Scand J Urol Nephrol. 1985;19(3):193-202. doi: 10.3109/00365598509180253.
The dynamic function of the urinary tract was studied in 6 infravesically obstructed pigs with vesico-ureteric reflux to a total of 8 ureters. After 10 weeks of obstruction a bladder hyperreflexia was found. The baseline ureteric activity in the refluxing ureters was reduced to a median of 0.3 A.P./min (action potentials/min). During bladder filling, the activity increased only slightly to 0.6 A.P./min. In the start the pelvic pressure was more or less independent of the bladder pressure, but when the reflux producing bladder pressure was reached then an abrupt increase in pelvic pressure was seen and thereafter there was pressure equilibration. Ten weeks after release of the obstruction, a minor restitution had taken place. The baseline activity during low urine output was 1.0 A.P./min and during bladder filling it was unaltered, 1.0 A.P./min. Even during high urine output there was no sign of activity increase. 30% of the ureteric contractions stopped in the mid-third of the ureter. Almost all peristalsis was antegrade. Thus, ureters subjected to obstruction and reflux showed deterioration of the peristaltic function and the changes were irreversible.
对6只存在膀胱下梗阻且伴有膀胱输尿管反流的猪的8条输尿管的尿路动态功能进行了研究。梗阻10周后发现膀胱反射亢进。反流输尿管的基线输尿管活动减少至中位数0.3次动作电位/分钟（动作电位/分钟）。在膀胱充盈期间，活动仅略有增加至0.6次动作电位/分钟。开始时，肾盂压力或多或少与膀胱压力无关，但当达到产生反流的膀胱压力时，可见肾盂压力突然增加，此后压力达到平衡。解除梗阻10周后，有轻微恢复。低尿量时的基线活动为1.0次动作电位/分钟，膀胱充盈时未改变，仍为1.0次动作电位/分钟。即使在高尿量时也没有活动增加的迹象。30%的输尿管收缩在输尿管中三分之一处停止。几乎所有蠕动都是顺行的。因此，遭受梗阻和反流的输尿管显示蠕动功能恶化，且这些变化是不可逆的。
