Huang Si-Qi, Yi Chang, Liu Xiao-Xuan, Yang Hao-Yu, Zhang Liang-Qi, Tang Yu, Zhang Xi-Li, Liu Wen-Long
School of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China.
School of Pharmacy, Hunan University of Chinese Medicine Changsha 410208, China Hunan Provincial Key Laboratory of Druggability and Preparation Modification of Traditional Chinese Medicine Changsha 410208, China.
Zhongguo Zhong Yao Za Zhi. 2024 Jun;49(11):2863-2870. doi: 10.19540/j.cnki.cjcmm.20240227.301.
Cinnamomum camphora chvar. borneol, a rare camphor tree variant recently identified in China, is distinguished by its high concentration of D-borneol, also known as " plant gold" due to its significant value. The essential oil extracted from this variant,rich in monoterpenes and sesquiterpenes, demonstrates a broad spectrum of pharmacological activities, including analgesic, antiinflammatory, antioxidant, cognition-enhancing, anti-bacterial, and insecticidal effects. These properties, underscored by extensive research, highlight the oil's potential in the biomedical, chemical, and food sectors as a valuable commodity. Nonetheless, the safety profile of this valuable oil remains poorly characterized, with its chemical composition and therapeutic efficacy subject to variations in the factors like geographic origin, harvesting timing, part used for extraction, and processing techniques. Such variability poses challenges to its clinical application and hampers the efficient exploitation of this resource. This review synthesizes current studies on C. camphora chvar. borneol essential oil and provides a detailed examination of its chemical and pharmacological profiles. In this study, we discuss existing research gaps and propose strategies for advancing its clinical use and industrial application, aiming to provide a foundational reference for future investigations and the resolution of its commercial and therapeutic challenges.
龙脑樟,一种最近在中国发现的珍稀樟树变种,其特点是富含右旋龙脑(D-龙脑),因其具有重要价值,也被称为“植物黄金”。从该变种中提取的精油富含单萜和倍半萜,具有广泛的药理活性,包括镇痛、抗炎、抗氧化、增强认知、抗菌和杀虫作用。大量研究强调了这些特性,突出了该精油在生物医学、化学和食品领域作为一种有价值商品的潜力。然而,这种珍贵精油的安全性特征仍不明确,其化学成分和治疗效果会因地理来源、收获时间、提取部位和加工技术等因素而有所不同。这种变异性对其临床应用构成挑战,并阻碍了对这一资源的有效开发。本综述综合了目前关于龙脑樟精油的研究,并对其化学和药理特性进行了详细分析。在本研究中,我们讨论了现有的研究空白,并提出了推进其临床应用和工业应用的策略,旨在为未来的研究以及解决其商业和治疗挑战提供基础参考。