Teerthanker Mahaveer College of Pharmacy, Teerthanker Mahaveer University, Moradabad 244001 (UP), India.
Department of Zoology, Krishna College of Science & Information Technology, Bijnor 246701 (UP), India.
Curr Pharm Des. 2024;30(32):2562-2573. doi: 10.2174/0113816128320161240703092622.
A unique extreme acute breathing syndrome emerged in China and spread rapidly globally due to a newly diagnosed human coronavirus and declared a pandemic. COVID-19 was formally named by WHO, and the Global Committee on Taxonomy referred to it as extreme Acute respiratory Syndrome Coronavirus-2 (SARS-CoV-2). Currently there is no efficient method to control the extent of SARS-CoV-2 other than social distancing and hygiene activities. This study aims to present a simple medicinal strategy for combating fatal viral diseases like COVID-19 with minimum effort and intervention. Different Ayurveda medicines (, green tea, and ) inhibit virus entrance and pathogen transmission while also enhancing immunity. Piperine (1-piperoylpiperidine), as well as curcumin, combine to create an intermolecular complex (π- π) that improves curcumin bioavailability by inhibiting glucuronidation of curcumin in the liver. The receptor- binding domains of the S-protein and also the angiotensin-converting enzyme 2 receptor of the recipient organism are directly occupied by curcumin and catechin, respectively, thereby preventing viruses from entering the cell. As a result, the infection will be tolerated by the animal host.
一种独特的极急性呼吸综合征在中国出现，并由于一种新诊断的人类冠状病毒而迅速在全球传播，并被宣布为大流行。COVID-19 由世界卫生组织正式命名，全球分类学委员会将其称为严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）。目前，除了社交距离和卫生活动外，没有有效的方法来控制 SARS-CoV-2 的传播范围。本研究旨在提出一种简单的药用策略，以最小的努力和干预来对抗 COVID-19 等致命性病毒疾病。不同的阿育吠陀药物（姜黄素、绿茶和胡椒碱）可以抑制病毒进入和病原体传播，同时增强免疫力。胡椒碱（1-胡椒酰基哌啶）与姜黄素结合，形成一种分子间复合物（π-π），通过抑制肝脏中姜黄素的葡萄糖醛酸化来提高姜黄素的生物利用度。S 蛋白的受体结合域和受体生物的血管紧张素转换酶 2 受体分别被姜黄素和儿茶素直接占据，从而阻止病毒进入细胞。因此，感染将被动物宿主耐受。
