Synthesis of indolines palladium-catalyzed [4 + 1] annulation of (2-aminophenyl)methanols with sulfoxonium ylides.
作者信息
Hao Erxiao, Kong Xiaomei, Xu Tongyu, Zeng Fanlong
机构信息
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, National Demonstration Center for Experimental Chemistry Education, College of Chemistry & Materials Science, Northwest University, 1 Xuefu Road, Xi'an, Shaanxi, 710127, P. R. China.
出版信息
Org Biomol Chem. 2024 Aug 7;22(31):6342-6351. doi: 10.1039/d4ob00983e.
A facile strategy for the synthesis of valuable indolines has been developed, involving a palladium(II)/Brønsted acid co-catalyzed annulation of readily available (2-aminophenyl)methanols and sulfoxonium ylides. This protocol allows for the direct utilization of the OH group as a leaving group, tolerates alkyl and aryl groups on the N atom of the aniline moiety, operates under mild reaction conditions, and exhibits good efficiency.
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