Dahlgren M Kathryn, Kosereisoglu Deniz, Sagar Kelly A, Smith Rosemary T, El-Abboud Celine, Lambros Ashley M, Gruber Staci A
Cognitive and Clinical Neuroimaging Core, McLean Imaging Center, McLean Hospital, Belmont, Massachusetts.
Marijuana Investigations for Neuroscientific Discovery (MIND) Program, McLean Hospital, Belmont, Massachusetts.
J Stud Alcohol Drugs. 2025 Jan;86(1):68-74. doi: 10.15288/jsad.24-00014. Epub 2024 Jul 23.
Previous research has demonstrated different cannabis-related outcomes depending on the goal of cannabis use (i.e., recreational, medical, a hybrid of both), underscoring the need to identify variables associated with specific goals of use, particularly in understudied populations.
This report used data from a national survey of menopausal individuals using nonprobability sampling. Respondents reporting current regular (≥1x/month) cannabis use (medical = 35; recreational = 61; and hybrid = 102) were included in multivariate logistic regression analyses examining demographic, clinical (e.g., menopause-related symptomatology), and cannabis-related variables associated with the goal of cannabis use.
Overall, an increased number of medical conditions was associated with medical and hybrid use relative to recreational use (s ≤ .047), and greater menopause-related symptomatology was associated with medical relative to hybrid use ( = .001). Lower education level was associated with hybrid relative to recreational use ( = .010). Lastly, more varied modes of use was associated with hybrid use relative to medical and recreational use (s ≤ .001).
Results suggest that medical and hybrid consumers with more medical conditions and more severe clinical symptoms that are not sufficiently alleviated by conventional treatments may be more open to cannabinoid-based therapies. In addition, because a lower education level is often associated with recreational cannabis use, results suggest that hybrid consumers may begin as recreational consumers who then expand their use for medical purposes. Further, more varied modes of use for hybrid consumers may reflect different product selections based on the goal of use. Future research should investigate the etiology of hybrid cannabis use and predictors of long-term outcomes associated with goals of use.
先前的研究表明，根据大麻使用的目的（即娱乐性、医疗性、两者混合），会产生不同的与大麻相关的结果，这凸显了识别与特定使用目的相关变量的必要性，尤其是在研究较少的人群中。
本报告使用了一项对更年期个体进行的全国性非概率抽样调查的数据。报告当前经常（≥每月1次）使用大麻的受访者（医疗性使用 = 35人；娱乐性使用 = 61人；混合性使用 = 102人）被纳入多变量逻辑回归分析，以检验与大麻使用目的相关的人口统计学、临床（如更年期相关症状）和大麻相关变量。
总体而言，相对于娱乐性使用，医疗状况数量的增加与医疗性和混合性使用相关（P≤0.047），相对于混合性使用，更多的更年期相关症状与医疗性使用相关（P = 0.001）。相对于娱乐性使用，较低的教育水平与混合性使用相关（P = 0.010）。最后，相对于医疗性和娱乐性使用，更多样化的使用方式与混合性使用相关（P≤0.001）。
结果表明，患有更多医疗状况且常规治疗无法充分缓解的更严重临床症状的医疗性和混合性消费者可能对基于大麻素的疗法更开放。此外，由于较低的教育水平通常与娱乐性大麻使用相关，结果表明混合性消费者可能最初是娱乐性消费者，然后将其使用扩展到医疗目的。此外，混合性消费者更多样化的使用方式可能反映了基于使用目的不同的产品选择。未来的研究应调查混合性大麻使用的病因以及与使用目的相关的长期结果的预测因素。
