Department of Kinesiology and Health, Rutgers University, New Brunswick, NJ, USA.
Curr Top Behav Neurosci. 2024;67:157-175. doi: 10.1007/7854_2024_496.
Depression is among the world's leading causes of disability and accounts for a significant loss of life. Despite large investments in research for antidepressants and psychotherapies, non-response, partial response, and small effects remain significant problems. Exercise and physical activity are two lifestyle behaviors that have been studied for well over half a century for the prevention and treatment of depression. The aim of this chapter is to summarize the current evidence base supporting the efficacy of exercise and physical activity in the prevention and treatment of depression, including evidence supporting exercise as a monotherapy and adjunct to antidepressant medication and psychotherapies. We conclude the chapter by outlining challenges to prescribing exercise for depression and general recommendations for encouraging behavioral adoption for individuals suffering from depression.
抑郁症是世界上导致残疾的主要原因之一，也是造成大量生命损失的重要原因。尽管在抗抑郁药和心理疗法的研究上投入了大量资金，但无反应、部分反应和效果小仍然是重大问题。运动和体育活动是两种生活方式行为，已经被研究了半个多世纪，用于预防和治疗抑郁症。本章的目的是总结目前支持运动和体育活动在预防和治疗抑郁症方面的疗效的证据基础，包括支持运动作为单一疗法以及作为抗抑郁药物和心理疗法的辅助疗法的证据。最后，我们概述了为抑郁症患者开运动处方的挑战，并提出了鼓励患有抑郁症的个人养成行为习惯的一般建议。
