泰国东北部一家三级转诊中心医院骨质疏松症患病率趋势：20 年分析（2003-2022 年）。

Trends in osteoporosis prevalence at a tertiary care referral center hospital in Northeastern Thailand: a 20-year analysis (2003-2022).

机构信息

Department of Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, MA, USA.

Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

出版信息

Arch Osteoporos. 2024 Jul 23;19(1):64. doi: 10.1007/s11657-024-01425-z.

DOI:10.1007/s11657-024-01425-z

PMID:39042274

Abstract

UNLABELLED

The current study aimed to investigate the prevalence trends of osteoporosis from 2003 to 2022 using data from the largest tertiary care referral center hospital in Northeastern Thailand. We reviewed 36,306 bone mineral density measurements of community-dwelling individuals aged > 45 years from the medical record database of Srinagarind Hospital, Khon Kaen, Thailand, between 2003 and 2022. We observed a significant increase in the crude prevalence of osteoporosis from 2003 to 2022. Meanwhile, the age-standardized prevalence increased more gradually.

PURPOSE

To investigate the prevalence trends of osteoporosis from 2003 to 2022 using data from the largest tertiary care referral center in Northeastern Thailand.

METHODS

Bone mineral density (BMD) measurements of community-dwelling individuals aged > 45 years were reviewed from the medical record database of Srinagarind Hospital, Khon Kaen, Thailand, between 2003 and 2022. Osteoporosis was defined by a T-score of ≤ - 2.5. For each year, crude and age-standardized prevalence rates for osteoporosis stratified by site of measurement were calculated. Trend analysis was performed using the joinpoint regression method.

RESULTS

A total of 36,306 BMD measurements were identified between 2003 and 2022. The crude prevalence of femoral neck (FN) osteoporosis increased from 2.4% to 9.2% in men and from 2.5% to 11.2% in women, while the age-standardized prevalence increased less, from 2.6% to 8.3% in men, and slightly decreased from 8.7% to 7.6% in women. Trend analysis revealed increased crude and age-standardized prevalence rates of FN osteoporosis in men, with an annual percent change (APC) of 4.0 (95%CI: - 4.1 to 14.7) and 2.3 (95%CI: - 4.9 to 10.0), respectively. In women, the crude prevalence increased significantly from 2003 to 2011 (APC: 20.8, 95%CI: 5.8-249.3) and plateaued from 2011 to 2022 (APC: 0.8, 95%CI: - 30.3 to 5.9). The age-standardized prevalence was relatively unchanged (APC: 0.1, 95%CI: - 4.2 to 5.4).

CONCLUSION

We observed a significant increase in the crude prevalence of osteoporosis from 2003 to 2022 among individuals receiving BMD measurements in a tertiary care referral center in Northeastern Thailand. Meanwhile, the age-standardized prevalence increased more gradually.

摘要

目的

利用来自泰国东北部最大的三级转诊中心的数据，调查 2003 年至 2022 年骨质疏松症的流行趋势。

方法

回顾了 2003 年至 2022 年间泰国孔敬府诗琳通医院病历数据库中 36306 名年龄大于 45 岁的社区居民的骨密度测量值。骨质疏松症定义为 T 评分≤-2.5。对于每一年，根据测量部位计算骨质疏松症的粗患病率和年龄标准化患病率。使用 joinpoint 回归方法进行趋势分析。

结果

共确定了 2003 年至 2022 年期间的 36306 次 BMD 测量值。男性股骨颈（FN）骨质疏松症的粗患病率从 2.4%增加到 9.2%，女性从 2.5%增加到 11.2%，而年龄标准化患病率增加较少，男性从 2.6%增加到 8.3%，女性则从 8.7%略有下降至 7.6%。趋势分析显示，男性 FN 骨质疏松症的粗患病率和年龄标准化患病率均呈上升趋势，年变化百分比（APC）分别为 4.0（95%CI：-4.1 至 14.7）和 2.3（95%CI：-4.9 至 10.0）。在女性中，粗患病率从 2003 年至 2011 年显著增加（APC：20.8，95%CI：5.8-249.3），并在 2011 年至 2022 年期间趋于平稳（APC：0.8，95%CI：-30.3 至 5.9）。年龄标准化患病率相对不变（APC：0.1，95%CI：-4.2 至 5.4）。