Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Science, Seoul National University, Seoul 08826, Republic of Korea.
Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10012, USA.
Poult Sci. 2024 Sep;103(9):103978. doi: 10.1016/j.psj.2024.103978. Epub 2024 Jun 24.
In poultry industry, the strategies for elevating of protein accretion with minimizing fat deposition have been applied, and seaweed algae has been focused one of the potential candidates. Accordingly, the purpose of this study was to investigate the effects of algae (Ascophllum Nodosum) extract (AE) on the growth performance and body composition of broiler chickens. A total of 240 one-day-old Ross 308 broiler chickens were allotted to 4 dietary treatment groups and fed experimental diets containing different concentrations of AE for 35 d as follows: 0 mg/kg (control, CON), 1,250 mg/kg (LAE), 2,500 mg/kg (MAE), or 5,000 mg/kg (HAE). At the end of the experiment, 40 chickens were sacrificed and samples of their blood, breast muscle, liver, and abdominal fat were collected and analyzed. Growth performance was improved in the LAE group compared to that in the CON (P < 0.05). The weight of abdominal fat was lower in the HAE group than in the CON group (P < 0.05). Serum triglyceride levels were also decreased in the HAE group compared to those in the CON and LAE groups (P < 0.05). Adipocytes were smaller in the HAE group than in all other treatments, and their size distribution was shifted more towards smaller adipocytes compared to those in the LAE group (P < 0.05). Relative mRNA levels in abdominal adipose tissue of fatty acid synthase and stearyl-CoA desaturase, which are involved in fatty acid synthesis, were all downregulated by supplementation with AE (P < 0.05). In addition, the protein levels of peroxisome proliferator-activated receptor gamma were decreased and the ratio of phosphorylated acetyl-CoA carboxylase to total ACC was increased, both of which indicate that lipogenesis was suppressed (P < 0.05). Hepatic transcript levels of sterol regulatory element-binding protein and its downstream enzymes fatty acid synthase and sterol-CoA desaturase were also lower in all AE treatments compared to those in the CON group (P < 0.05). These results indicate that the seaweed algae (Ascophllum Nodosum) extract reduces fat accumulation in both adipose tissue and the liver by modulating lipogenesis.
在禽类养殖业中，人们采用了提高蛋白质沉积量、减少脂肪沉积量的策略，而海藻已成为备受关注的潜在候选物质之一。因此，本研究旨在探讨海藻（Ascophllum Nodosum）提取物（AE）对肉鸡生长性能和体组成的影响。将 240 只 1 日龄 Ross 308 肉鸡随机分配到 4 个日粮处理组中，分别饲喂含有不同浓度 AE 的实验日粮 35 d，AE 浓度分别为 0 mg/kg（对照组，CON）、1250 mg/kg（LAE）、2500 mg/kg（MAE）和 5000 mg/kg（HAE）。试验结束时，随机选择 40 只鸡进行屠宰，采集血液、胸肌、肝脏和腹部脂肪样进行分析。与 CON 组相比，LAE 组的生长性能得到提高（P＜0.05）。HAE 组的腹部脂肪重量低于 CON 组（P＜0.05）。与 CON 和 LAE 组相比，HAE 组的血清三酰甘油水平降低（P＜0.05）。HAE 组的脂肪细胞小于其他处理组，且脂肪细胞大小分布向更小的脂肪细胞偏移，与 LAE 组相比差异显著（P＜0.05）。AE 补充剂下调了腹部脂肪组织中参与脂肪酸合成的脂肪酸合酶和硬脂酰辅酶 A 去饱和酶的相对 mRNA 水平（P＜0.05）。此外，过氧化物酶体增殖物激活受体γ的蛋白水平降低，磷酸化乙酰辅酶 A 羧化酶与总 ACC 的比值升高，这表明脂肪生成受到抑制（P＜0.05）。AE 处理组的肝组织固醇调节元件结合蛋白及其下游酶脂肪酸合酶和固醇-CoA 去饱和酶的转录水平也低于 CON 组（P＜0.05）。这些结果表明，海藻（Ascophllum Nodosum）提取物通过调节脂肪生成来减少脂肪在脂肪组织和肝脏中的积累。
