抗药性时代下噬菌体及其在饲养动物中应用的综述
A review of bacteriophage and their application in domestic animals in a post-antibiotic era.
机构信息
State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems, Ministry of Agriculture and Rural Affairs, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou 730020, China.
CAS Key Laboratory for Agro-Ecological Processes in Subtropical Region, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Hunan Provincial Key Laboratory of Animal Nutrition Physiology and Metabolic Process, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, China.
出版信息
Sci Total Environ. 2024 Nov 1;949:174931. doi: 10.1016/j.scitotenv.2024.174931. Epub 2024 Jul 21.
Bacteriophages (phages for short) are the most abundant biological entities on Earth and are natural enemies of bacteria. Genomics and molecular biology have identified subtle and complex relationships among phages, bacteria and their animal hosts. This review covers composition, diversity and factors affecting gut phage, their lifecycle in the body, and interactions with bacteria and hosts. In addition, research regarding phage in poultry, aquaculture and livestock are summarized, and application of phages in antibiotic substitution, phage therapy and food safety are reviewed.
噬菌体（简称 phages）是地球上最丰富的生物实体，是细菌的天然敌人。基因组学和分子生物学已经确定了噬菌体、细菌及其动物宿主之间微妙而复杂的关系。本综述涵盖了肠道噬菌体的组成、多样性和影响因素、它们在体内的生命周期以及与细菌和宿主的相互作用。此外，还总结了噬菌体在禽类、水产养殖和畜牧业中的研究，并回顾了噬菌体在抗生素替代、噬菌体治疗和食品安全中的应用。
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