在未发生抗病毒耐药的情况下，使用替诺福韦/恩曲他滨治疗时，HIV-HBV 疫苗逃逸突变感染可导致 HBV 表面抗体丧失和持续性 HBV 病毒血症。
HIV-HBV vaccine escape mutant infection with loss of HBV surface antibody and persistent HBV viremia on tenofovir/emtricitabine without antiviral resistance.
机构信息
Department of Veterans Affairs, Office of Public Health, Palo Alto, CA 94304, USA.
出版信息
J Clin Virol. 2011 Nov;52(3):261-4. doi: 10.1016/j.jcv.2011.07.014. Epub 2011 Aug 12.
PMID:21840252
Abstract
We report a case of acute hepatitis B virus genotype A vaccine escape mutant infection with loss of HBV vaccine-induced seropositivity in a HIV-1 infected patient. His HBV is unresponsive to tenofovir/emtricitabine treatment demonstrated by persistent viremia despite lacking known resistance mutations and while having an undetectable HIV-1 viral load.
摘要
我们报告了一例急性乙型肝炎病毒基因型 A 疫苗逃逸突变感染病例，该病例发生在一名 HIV-1 感染患者中，导致 HBV 疫苗诱导的血清学阳性反应丧失。尽管缺乏已知的耐药突变，但他的 HBV 对替诺福韦/恩曲他滨治疗无反应，表现为持续病毒血症，而 HIV-1 病毒载量无法检测。
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