Am J Cardiol. 1985 Nov 22;56(14):23G-26G.
The effect of metoprolol on the development of an acute myocardial infarction (AMI) during days 0 to 3 and on late first and recurrent infarctions during days 4 to 15 has been investigated. Signs on electrocardiogram (ECG) were well balanced between the treatment groups at entry; 70% of patients had signs of suspected AMI and 19% of patients had normal ECGs. The remaining patients had abnormal ECGs but actual infarction could not be localized. The localization of suspected AMI was equivalently distributed in the 2 groups before randomization. Metoprolol altered the distribution of patients diagnosed during days 0 to 3 as having definite, possible or no AMI (p less than 0.02). In the placebo group, there were more patients with definite AMI (72.5% vs 70.5%) and less with possible AMI (5.6% vs 7.4) than in the metoprolol group. A larger proportion of patients developed a Q-wave infarction during days 0 to 3 in the placebo group (53.9%) compared with the metoprolol group (50.9%, p = 0.024). No difference in the effect of metoprolol regarding localization of the early AMI was observed. Late first myocardial infarction development (days 4 to 15) was observed in 20 patients (0.7%) in each group. Recurrent myocardial infarction tended to develop more frequently during days 4 to 15 in the placebo group compared with the metoprolol group (3.9% vs 3.0%, p = 0.08).(ABSTRACT TRUNCATED AT 250 WORDS)
已对美托洛尔在第0至3天对急性心肌梗死（AMI）发生的影响以及在第4至15天对首次晚期梗死和复发性梗死的影响进行了研究。入组时治疗组间心电图（ECG）表现均衡；70%的患者有疑似AMI表现，19%的患者ECG正常。其余患者ECG异常但无法定位实际梗死部位。随机分组前，疑似AMI的定位在两组中分布相当。美托洛尔改变了在第0至3天被诊断为明确、可能或无AMI的患者分布情况（p<0.02）。与美托洛尔组相比，安慰剂组中明确AMI的患者更多（72.5%对70.5%），可能AMI的患者更少（5.6%对7.4%）。与美托洛尔组（50.9%，p=0.024）相比，安慰剂组在第0至3天有更大比例的患者发生Q波梗死（53.9%）。未观察到美托洛尔对早期AMI定位的影响存在差异。每组有20名患者（0.7%）发生晚期首次心肌梗死（第4至15天）。与美托洛尔组相比，安慰剂组在第4至15天复发性心肌梗死的发生频率更高（3.9%对3.0%，p=0.08）。（摘要截短至250字）
