Am J Cardiol. 1985 Nov 22;56(14):10G-14G.
During the recruitment phase of the MIAMI trial (December 1982 to March 1984), data on 26,439 patients eligible for inclusion were entered. Of these, 5,778 patients were included. Current treatment with either beta blockers or calcium-channel blockers (51%) was the most predominant reason for exclusion. The randomized and excluded patients differed. The randomized patients were younger and more often men. The mean age of the patients was 59 years in both the placebo and the metoprolol groups. The 2 groups were evenly balanced with regard to basic demographic variables. The median delay between onset of symptoms and randomization was 7 hours, and 25% of the patients were included within 4 hours. Previous clinical history and pharmacologic treatment given before admission were well balanced in the groups. Mean heart rate for the 2 groups before randomization was 83 beats/min and systolic blood pressure was 141 mm Hg. Approximately 15% of randomized patients presented with pulmonary rales. Before randomization 20% of the patients had normal electrocardiograms; 70% could be classified as having electrocardiographic signs of acute myocardial infarction; and 10% presented with other electrocardiographic abnormalities. Electrocardiographic signs at entry suggested a predominance of anterior wall infarctions. The randomized patients were not representative of eligible patients and the treatment groups were well balanced at entry.
在迈阿密试验的招募阶段（1982年12月至1984年3月），录入了26439名符合纳入标准患者的数据。其中，5778名患者被纳入。当前正在使用β受体阻滞剂或钙通道阻滞剂进行治疗（51%）是排除的最主要原因。随机分组患者与被排除患者有所不同。随机分组患者更年轻，男性比例更高。安慰剂组和美托洛尔组患者的平均年龄均为59岁。两组在基本人口统计学变量方面均衡。症状发作至随机分组的中位延迟时间为7小时，25%的患者在4小时内被纳入。两组入院前的既往临床病史和药物治疗情况均衡。随机分组前两组的平均心率为83次/分钟，收缩压为141 mmHg。约15%的随机分组患者出现肺部啰音。随机分组前，20%的患者心电图正常；70%可归类为有急性心肌梗死的心电图表现；10%有其他心电图异常。入组时的心电图表现提示前壁梗死占优势。随机分组患者不具有符合条件患者的代表性，且治疗组在入组时均衡。
