Am J Cardiol. 1985 Nov 22;56(14):39G-46G.
Fifteen minutes after injection there was a fall in mean heart rate (18%, p less than 0.001), systolic blood pressure (10%, p less than 0.001) and rate-pressure product (27%, p less than 0.0001) in the metoprolol group of patients in the MIAMI trial. Hypotension and bradycardia not necessarily associated with withdrawal of drug were more common in the metoprolol group (p less than 0.001). Atrioventricular block I was more common in the metoprolol group (p less than 0.03), whereas no such difference was observed for atrioventricular block II and III, asystole or pacemaker implantations. Left ventricular failure was observed no more often in the metoprolol group. The occurrence of cardiogenic shock also did not differ between the groups. Cardiac glycosides were used more in the placebo group, but diuretic and furosemide usage did not differ. For all patients mean furosemide doses and number of diuretic injections were similar in both treatment groups. Atropine (4.1 vs 6.4%) and sympathomimetic (3.2 vs 4.6%) agents were used more often in the metoprolol group during days 0 to 5 (p less than 0.05). The trial medication was withdrawn temporarily more often in the metoprolol than in the placebo group (p less than 0.001). However, permanent withdrawal of trial medication occurred with a similar frequency overall in both groups. More patients were withdrawn from the study because of cardiovascular reasons in the metoprolol group (9%) than in the placebo group (5%, p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
在迈阿密试验中，美托洛尔组患者注射药物15分钟后，平均心率下降（18%，p<0.001），收缩压下降（10%，p<0.001），心率血压乘积下降（27%，p<0.0001）。美托洛尔组低血压和心动过缓（不一定与停药有关）更为常见（p<0.001）。一度房室传导阻滞在美托洛尔组更为常见（p<0.03），而二度和三度房室传导阻滞、心脏停搏或起搏器植入方面未观察到此类差异。美托洛尔组左心室衰竭的发生率并未更高。两组之间心源性休克的发生率也无差异。安慰剂组使用强心苷更多，但利尿剂和呋塞米的使用无差异。两个治疗组中所有患者的平均呋塞米剂量和利尿剂注射次数相似。在第0至5天，美托洛尔组更常使用阿托品（4.1%对6.4%）和拟交感神经药（3.2%对4.6%）（p<0.05）。美托洛尔组比安慰剂组更常临时停用试验药物（p<0.001）。然而，两组中试验药物永久停用的总体频率相似。美托洛尔组因心血管原因退出研究的患者（9%）多于安慰剂组（5%，p<0.001）。（摘要截断于250字）
