Papatsimpas Vasileios, Vrouva Sotiria, Papathanasiou George, Papadopoulou Marianna, Bouzineki Christina, Kanellopoulou Sophia, Moutafi Dimitra, Bakalidou Daphne
Physiotherapy Department, School of Health and Care Sciences, University of West Attica (UNIWA), 12243 Athens, Greece.
Laboratory of Neuromuscular and Cardiovascular Study of Motion (LANECASM), School of Health and Care Sciences, University of West Attica (UNIWA), 12243 Athens, Greece.
Brain Sci. 2023 Jul 22;13(7):1112. doi: 10.3390/brainsci13071112.
This randomized controlled trial aims to investigate the effect of 12 weeks of therapeutic exercise on cognitive function and daily activities in patients with mild Alzheimer's disease (AD). A total of 171 patients with mild AD from the Amarousion Day Care Center of the Alzheimer Society of Athens and the Athens General Hospital "G. Gennimatas" were randomly divided into three groups. Group A (aerobic and resistance exercise, = 57), group B (resistance exercise, = 57), and group C (control group, = 57). Group A followed a weekly program consisting of 5 days with 30 min walking and 3 days with resistance exercises for about 45 min. Group B followed only a resistance exercise program, the same as group A. Group C did not participate in any exercise program. After the intervention, cognitive function was assessed with the Cognitive Examination-Revised (ACE-R), Trail Making Test A-B (TMT A-B), and Digit Span Test Forward and Backward (DST F-B) and daily activities with the instrumental activities of daily living scale (IADLs). A significant intervention effect was observed for all outcome measures (global cognitive function and instrumental activities of daily living). ANCOVA Bonferroni corrected post hoc tests revealed that the aerobic and resistance group improved compared to the control group on all measurement scales. The resistance group also showed an improvement compared to the control group. No significant effects were found between the aerobic and resistance group and the resistance group in any of the outcome measures.
这项随机对照试验旨在研究为期12周的治疗性运动对轻度阿尔茨海默病（AD）患者认知功能和日常活动的影响。来自雅典阿尔茨海默病协会阿马鲁西翁日间护理中心和雅典综合医院“G. 杰尼马塔斯”的171例轻度AD患者被随机分为三组。A组（有氧运动和抗阻运动，n = 57），B组（抗阻运动，n = 57），C组（对照组，n = 57）。A组遵循每周的计划，包括5天每天30分钟的步行和3天每天约45分钟的抗阻运动。B组仅遵循与A组相同的抗阻运动计划。C组不参与任何运动计划。干预后，使用修订版认知检查（ACE-R）、连线测验A-B（TMT A-B）和数字广度顺背测验（DST F-B）评估认知功能，使用日常生活能力量表（IADLs）评估日常活动。所有结局指标（整体认知功能和日常生活工具性活动）均观察到显著的干预效果。协方差分析经Bonferroni校正的事后检验显示，有氧运动和抗阻组在所有测量量表上与对照组相比均有改善。抗阻组与对照组相比也有改善。有氧运动和抗阻组与抗阻组在任何结局指标上均未发现显著差异。
