Li Xiao-Kun
The International Institute of Growth Factors, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.
Zhonghua Nan Ke Xue. 2024 Jan;30(1):3-8.
The testis serves as the reproductive gland in male mammals, primarily tasked with the production of sperm and synthesis of androgens. A complex signaling network consisting of various cell types, including germ cells, Sertoli cells, and Leydig cells, supports the structure and maintains the function of the testis. Apart from the hypothalamic-pituitary-gonadal axis, various sex hormones and cytokines are also implicated in the regulation of testicular function. The fibroblast growth factor (FGF) represents a crucial class of active cytokines that stimulate cell proliferation, induce tissue differentiation, and govern organ development. This review summarizes the molecular mechanisms of FGF regulating testicular development and spermatogenesis and maintaining male fertility.
睾丸是雄性哺乳动物的生殖腺，主要负责精子的产生和雄激素的合成。一个由各种细胞类型组成的复杂信号网络，包括生殖细胞、支持细胞和间质细胞，维持着睾丸的结构并支持其功能。除下丘脑-垂体-性腺轴外，各种性激素和细胞因子也参与睾丸功能的调节。成纤维细胞生长因子（FGF）是一类关键的活性细胞因子，可刺激细胞增殖、诱导组织分化并调控器官发育。本文综述了FGF调节睾丸发育、精子发生及维持雄性生育力的分子机制。
