The First Hospital of Jilin University, Changchun 130021, China ; KCHRI at the Department of Pediatrics, The University of Louisville, Louisville 40202, USA.
J Diabetes Res. 2013;2013:489095. doi: 10.1155/2013/489095. Epub 2013 Sep 18.
Fibroblast growth factors (FGFs) are classically known as hormonal factors and recent studies have revealed that FGFs have a key role in regulating growth and development of several reproductive organs, including the testis. The testis is mainly consisted of germ cells, Sertoli cells and Leydig cells to develop and maintain the male phenotype and reproduction. This review summarizes the structure and fuctions of testis, the roles of FGFs on testicular development and potential involvement in testicular tumor and its regulatory mechanism. Among 23 members of FGFs, the FGF-1, FGF-2, FGF-4, FGF-8, FGF-9, and FGF-21 were involved and describe in details. Understanding the roles and mechanism of FGFs is the foundation to modeling testicular development and treatments in testicular disease. Therefore, in the last part, the potential therapy with FGFs for the testis of cancer and diabetes was also discussed.
成纤维细胞生长因子（FGFs）通常被认为是激素因子，最近的研究表明，FGFs 在调节包括睾丸在内的几种生殖器官的生长和发育中起着关键作用。睾丸主要由生殖细胞、支持细胞和间质细胞组成，以发育和维持男性表型和生殖功能。本综述总结了睾丸的结构和功能、FGFs 在睾丸发育中的作用及其在睾丸肿瘤中的潜在作用及其调控机制。在 23 种 FGFs 中，FGF-1、FGF-2、FGF-4、FGF-8、FGF-9 和 FGF-21 被涉及并详细描述。了解 FGFs 的作用和机制是模拟睾丸发育和治疗睾丸疾病的基础。因此，在最后一部分，还讨论了 FGFs 治疗癌症和糖尿病睾丸的潜在疗法。
