Pazzaglia U E, Ceciliani L, Wilkinson M J, Dell'Orbo C
Arch Orthop Trauma Surg (1978). 1985;104(3):164-74. doi: 10.1007/BF00454694.
Four loosened metal-on-plastic total hip prostheses and associated tissues were examined. Each implant showed an uncommonly high formation of metal particles produced by wear or corrosion of the femoral stem. The granulation tissue between bone and cement was characterized by macrophages containing metal particles. Histological, histochemical, and ultrastructural investigations have been performed to assess cellular reactions to ingested metal particles. Pathogenesis of loosening in these cases is discussed in relation to the role of macrophages in bone resorption.
对四个松动的金属对塑料全髋关节假体及相关组织进行了检查。每个植入物都显示出由于股骨柄磨损或腐蚀而产生的金属颗粒形成异常高。骨与骨水泥之间的肉芽组织以含有金属颗粒的巨噬细胞为特征。已进行组织学、组织化学和超微结构研究以评估细胞对摄入金属颗粒的反应。结合巨噬细胞在骨吸收中的作用讨论了这些病例中松动的发病机制。
