Neurocybernetics and Rehabilitation, Dept. of Neurology, Otto-von-Guericke University Magdeburg, Leipziger Straße 44, 39120, Magdeburg, Germany; Center for Behavioral Brain Sciences, Otto-von-Guericke University, Magdeburg, Germany.
Dept. of Stereotactic Neurosurgery, Otto-von-Guericke University, Magdeburg, Germany.
Neurosci Biobehav Rev. 2021 Jul;126:146-158. doi: 10.1016/j.neubiorev.2021.02.046. Epub 2021 Mar 15.
Extensive neuroanatomical connectivity between the anterior thalamic nuclei (ATN) and hippocampus and neocortex renders them well-placed for a role in memory processing, and animal, lesion, and neuroimaging studies support such a notion. The deep location and small size of the ATN have precluded their real-time electrophysiological investigation during human memory processing. However, ATN electrophysiological recordings from patients receiving electrodes implanted for deep brain stimulation for pharmacoresistant focal epilepsy have enabled high temporal resolution study of ATN activity. Theta frequency synchronization of ATN and neocortical oscillations during successful memory encoding, enhanced phase alignment, and coupling between ATN local gamma frequency activity and frontal neocortical and ATN theta oscillations provide evidence of an active role for the ATN in memory encoding, potentially integrating information from widespread neocortical sources. Greater coupling of a broader gamma frequency range with theta oscillations at rest than during memory encoding provides additional support for the hypothesis that the ATN play a role in selecting local, task-relevant high frequency activity associated with particular features of a memory trace.
前丘脑核（ATN）与海马体和新皮层之间广泛的神经解剖连接使它们非常适合在记忆处理中发挥作用，动物、损伤和神经影像学研究支持了这一观点。ATN 的深部位置和小尺寸使得它们在人类记忆处理过程中无法进行实时电生理研究。然而，接受深部脑刺激电极植入以治疗耐药性局灶性癫痫的患者的 ATN 电生理记录，使我们能够以高时间分辨率研究 ATN 活动。在成功的记忆编码过程中，ATN 和新皮层振荡的θ频率同步、相位对准增强以及 ATN 局部γ频率活动与额叶新皮层和 ATNθ振荡之间的耦合，为 ATN 在记忆编码中发挥积极作用提供了证据，可能整合了来自广泛新皮层源的信息。与记忆编码期间相比，休息时更广泛的γ频带与θ振荡的耦合程度更高，这为 ATN 在选择与记忆痕迹特定特征相关的局部、任务相关的高频活动方面发挥作用的假设提供了额外的支持。
