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孕期淋巴细胞在淋巴器官间的迁移模式。 （注：原文Splenocytes指脾细胞，thymocytes指胸腺细胞，这里整体意译为淋巴细胞使表达更符合中文习惯）

Splenocytes and thymocytes migration patterns between lymphoid organs in pregnancy.

作者信息

Cruz-Cureño Gabriela T, Rosales-Tarteaut Marina Ch, Arriaga-Pizano Lourdes A, Sánchez-Torres Luvia E, Castro-Eguiluz Denisse, Prieto-Chávez Jessica L, Pastelin-Palacios Rodolfo, Flisser Ana, Cérbulo-Vázquez Arturo

机构信息

Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Prolongación Carpio s/n esq, Plan de Ayala, Plutarco Elías Calles, CP 11340, Ciudad de México, Mexico.

Unidad de Investigación Médica en Inmunoquímica, Centro de Instrumentos, Hospital de Especialidades, CMN Siglo XXI, Av. Cuahutemoc 330, Doctores, CP 06725, Ciudad de México, Mexico.

出版信息

Biochem Biophys Rep. 2024 Jul 2;39:101769. doi: 10.1016/j.bbrep.2024.101769. eCollection 2024 Sep.

DOI:10.1016/j.bbrep.2024.101769
PMID:39050011
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11268130/
Abstract

BACKGROUND

Cell migration is essential for the immune system and is frequently analyzed in adult non-pregnant animals but poorly explored in pregnant animals. However, a physiologic increased size in the spleen and periaortic lymph nodes had been reported in pregnant mice.

METHODS

Using a mouse model, we transferred PKH26-stained thymocytes and splenocytes from pregnant or non-pregnant animals to receptor mice in the presence or absence of pregnancy. Percentage of PKH-26 cells and Mean Fluorescence Intensity were calculated. Non-parametric ANOVA analysis was performed.

RESULTS

We detected that the percentage of PKH26+ thymocytes in the spleen, lymph nodes, and peripheral blood is higher in females than in males (p = 0.039). Our results showed a similar frequency of thymocytes and splenocytes from pregnant and non-pregnant mice located in receptor lymphoid organs (p > 0.05). Also, the location of marked cells was similar during the perinatal period (p > 0.05).

CONCLUSIONS

The mobility of thymocytes and splenocytes in pregnant and non-pregnant mice is similar. Therefore, we suggest that the larger size of the spleen and periaortic lymph nodes noted previously in pregnant mice could result from the retention of leukocytes in the secondary lymphoid organs.

摘要

背景

细胞迁移对免疫系统至关重要，在成年非妊娠动物中经常进行分析，但在妊娠动物中研究较少。然而，有报道称妊娠小鼠的脾脏和主动脉旁淋巴结生理性增大。

方法

使用小鼠模型，我们在有或无妊娠的情况下，将用PKH26染色的来自妊娠或非妊娠动物的胸腺细胞和脾细胞转移到受体小鼠体内。计算PKH-26细胞的百分比和平均荧光强度。进行非参数方差分析。

结果

我们检测到，雌性小鼠脾脏、淋巴结和外周血中PKH26+胸腺细胞的百分比高于雄性小鼠（p = 0.039）。我们的结果显示，来自妊娠和非妊娠小鼠的胸腺细胞和脾细胞在受体淋巴器官中的频率相似（p > 0.05）。此外，围产期标记细胞的位置相似（p > 0.05）。

结论

妊娠和非妊娠小鼠中胸腺细胞和脾细胞的迁移率相似。因此，我们认为，先前在妊娠小鼠中观察到的脾脏和主动脉旁淋巴结较大可能是由于白细胞滞留在二级淋巴器官中所致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/566d/11268130/7e36e4d86130/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/566d/11268130/cf3836cf8c79/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/566d/11268130/f5877a56f18d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/566d/11268130/7047db08fe77/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/566d/11268130/7e36e4d86130/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/566d/11268130/cf3836cf8c79/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/566d/11268130/f5877a56f18d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/566d/11268130/7047db08fe77/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/566d/11268130/7e36e4d86130/gr4.jpg

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本文引用的文献

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Clocking in to immunity.时钟进入免疫。
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Plasticity and heterogeneity of lymphoid organs. What are the criteria to call a lymphoid organ primary, secondary or tertiary?淋巴器官的可塑性和异质性。将一个淋巴器官称为一级、二级或三级淋巴器官的标准是什么？
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Promotion of lymphocyte egress into blood and lymph by distinct sources of sphingosine-1-phosphate.不同来源的1-磷酸鞘氨醇促进淋巴细胞进入血液和淋巴。
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