Joseph Ranjana E, Sathishkumar Dharshini, Gupta Ankan, Korula Sophy
Department of Dermatology, Paediatric Endocrinology and Metabolism Division, Christian Medical College, Vellore, Tamil Nadu, India.
Department of Pediatrics, Paediatric Endocrinology and Metabolism Division, Christian Medical College, Vellore, Tamil Nadu, India.
Indian Dermatol Online J. 2024 Jun 26;15(4):605-611. doi: 10.4103/idoj.idoj_729_23. eCollection 2024 Jul-Aug.
There is only limited data on the association between psoriasis and metabolic comorbidities in South-Asian children.
To examine metabolic comorbidities among South-Asian children with and without psoriasis.
A hospital-based, comparative, cross-sectional study was conducted in children with and without psoriasis over 19 months. Anthropometric, clinical, and metabolic comorbidity details (including disease extent and severity scores, obesity, systemic hypertension, diabetes mellitus, lipid abnormalities, and metabolic syndrome) were obtained in both groups according to standard criteria.
Fifty-eight children with psoriasis (25 males/33 females, age 11.3 ± 3.0 years, range 4 to 17 years) and 62 children without psoriasis (37 males/25 females, age 11.0 ± 3.6 years, range 4 to 18 years) were recruited. The prevalence of obesity (31.0% versus 14.5%, = 0.031, odds ratio 2.65) and metabolic syndrome (18.6% versus 4.6%, = 0.044, odds ratio 4.68) were higher in children with psoriasis than without. The prevalence of other metabolic comorbidities (systemic hypertension, pre-diabetes, lipid abnormalities, elevated serum alanine aminotransferase, and non-alcoholic fatty liver disease) was not different between children with and without psoriasis and between obese and non-obese children with psoriasis. Among children with psoriasis, those with abdominal obesity had significantly lower disease severity and extent scores than those without.
Psoriasis is associated with a significantly higher prevalence of obesity and close to significantly higher prevalence of metabolic syndrome in South-Asian children. Screening for metabolic comorbidities is essential even in non-obese children with psoriasis. Disease extent and severity are less in obese compared to non-obese South-Asian children with psoriasis.
关于南亚儿童银屑病与代谢性共病之间关联的数据有限。
研究有和没有银屑病的南亚儿童的代谢性共病情况。
对患有和未患银屑病的儿童进行了一项为期19个月的基于医院的比较性横断面研究。根据标准标准，在两组中获取了人体测量、临床和代谢性共病的详细信息（包括疾病范围和严重程度评分、肥胖、系统性高血压、糖尿病、血脂异常和代谢综合征）。
招募了58名银屑病患儿（25名男性/33名女性，年龄11.3±3.0岁，范围4至17岁）和62名无银屑病患儿（37名男性/25名女性，年龄11.0±3.6岁，范围4至18岁）。银屑病患儿的肥胖患病率（31.0%对14.5%，P=0.031，比值比2.65）和代谢综合征患病率（18.6%对4.6%，P=0.044，比值比4.68）高于无银屑病患儿。其他代谢性共病（系统性高血压、糖尿病前期、血脂异常、血清丙氨酸氨基转移酶升高和非酒精性脂肪性肝病）的患病率在有和无银屑病的儿童之间以及肥胖和非肥胖的银屑病患儿之间没有差异。在银屑病患儿中，腹部肥胖的患儿疾病严重程度和范围评分显著低于无腹部肥胖的患儿。
在南亚儿童中，银屑病与肥胖患病率显著升高以及代谢综合征患病率近乎显著升高相关。即使在非肥胖的银屑病患儿中，筛查代谢性共病也至关重要。与非肥胖的南亚银屑病患儿相比，肥胖患儿的疾病范围和严重程度较低。
