Department of Dermatology, Venereology, and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Department of Radiodiagnosis and Imaging, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Clin Exp Dermatol. 2023 Jan 20;48(1):12-19. doi: 10.1093/ced/llac028.
Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent comorbidity in adult patients with psoriasis, but there is a paucity of data on NAFLD in paediatric patients with psoriasis.
To estimate the prevalence of NAFLD in children and adolescents with psoriasis compared with age- and sex-matched healthy controls (HCs) and to evaluate risk factors for NAFLD in paediatric psoriasis.
This was a cross-sectional study performed from July 2019 to December 2020 in a single tertiary care centre, which enrolled 52 children/adolescents aged 2-18 years diagnosed with psoriasis at least 6 months previously, and 52 HCs matched for age and sex. Anthropometric, metabolic and radiological assessment was performed for all participants. NAFLD prevalence was determined by liver enzyme (serum glutamic pyruvic transferase) levels, ultrasonography, shear wave elastography and aspartate aminotransferase/platelet index. Multivariate analysis was performed to determine the independent risk factors for NAFLD.
The frequency of NAFLD was found to be 28·8% in patients with paediatric psoriasis compared with 3·8% in HCs. Logistic regression showed that greater disease severity (Psoriasis Area and Severity Index ≥ 10), obesity and decreased high-density lipoprotein cholesterol (HDL-C) level were independently associated with NAFLD, and thus can be considered risk factors for NAFLD.
Patients with paediatric psoriasis have a higher prevalence of NAFLD compared with HCs. Children who are obese or have moderate to severe psoriasis or decreased HDL-C levels are at a higher risk of developing NAFLD.
非酒精性脂肪性肝病（NAFLD）是成人银屑病患者的一种高发合并症，但儿童银屑病患者的 NAFLD 数据较少。
评估与年龄和性别匹配的健康对照组（HCs）相比，患有银屑病的儿童和青少年中 NAFLD 的患病率，并评估儿童银屑病中 NAFLD 的危险因素。
这是一项在 2019 年 7 月至 2020 年 12 月在一家三级护理中心进行的横断面研究，纳入了 52 名年龄在 2-18 岁之间、至少 6 个月前被诊断为银屑病的儿童/青少年患者，以及 52 名年龄和性别匹配的 HCs。所有参与者均进行了人体测量、代谢和影像学评估。通过肝酶（血清谷氨酸丙酮酸转移酶）水平、超声、剪切波弹性成像和天冬氨酸氨基转移酶/血小板指数来确定 NAFLD 的患病率。进行多变量分析以确定 NAFLD 的独立危险因素。
与 HCs 相比，患有儿童银屑病的患者中 NAFLD 的发生率为 28.8%。logistic 回归显示，疾病严重程度较高（银屑病面积和严重程度指数≥10）、肥胖和高密度脂蛋白胆固醇（HDL-C）水平降低与 NAFLD 独立相关，因此可被视为 NAFLD 的危险因素。
与 HCs 相比，患有儿童银屑病的患者 NAFLD 的患病率更高。肥胖或患有中重度银屑病或 HDL-C 水平降低的儿童患 NAFLD 的风险更高。
