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海马体DNA甲基化的辐射与改变

Irradiation and Alterations in Hippocampal DNA Methylation.

作者信息

Impey Soren, Raber Jacob

机构信息

Dow Neurobiology Laboratories, Legacy Research Institute Legacy Health Systems, 1225 NE 2nd Ave, Portland, OR 97232, USA.

Departments of Behavioral Neuroscience, Neurology, and Radiation Medicine, Division of Neuroscience, ONPRC, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.

出版信息

Epigenomes. 2024 Jul 5;8(3):27. doi: 10.3390/epigenomes8030027.

DOI:10.3390/epigenomes8030027
PMID:39051185
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11270359/
Abstract

The response of the brain to radiation is important for cancer patients receiving whole or partial brain irradiation or total body irradiation, those exposed to irradiation as part of a nuclear accident or a nuclear war or terrorism event, and for astronauts during and following space missions. The mechanisms mediating the effects of irradiation on the hippocampus might be associated with alterations in hippocampal DNA methylation. Changes in cytosine methylation involving the addition of a methyl group to cytosine (5 mC) and especially those involving the addition of a hydroxy group to 5 mC (hydroxymethylcytosine or 5 hmC) play a key role in regulating the expression of genes required for hippocampal function. In this review article, we will discuss the effects of radiation on hippocampal DNA methylation and whether these effects are associated with hippocampus-dependent cognitive measures and molecular measures in the hippocampus involved in cognitive measures. We will also discuss whether the radiation-induced changes in hippocampal DNA methylation show an overlap across different doses of heavy ion irradiation and across irradiation with different ions. We will also discuss whether the DNA methylation changes show a tissue-dependent response.

摘要

大脑对辐射的反应对于接受全脑或部分脑照射、全身照射的癌症患者，因核事故、核战争或恐怖主义事件而受到辐射的人群，以及太空任务期间及之后的宇航员来说都很重要。介导辐射对海马体影响的机制可能与海马体DNA甲基化的改变有关。胞嘧啶甲基化的变化，包括向胞嘧啶添加甲基（5-甲基胞嘧啶或5mC），特别是向5mC添加羟基（羟甲基胞嘧啶或5hmC）的变化，在调节海马体功能所需基因的表达中起关键作用。在这篇综述文章中，我们将讨论辐射对海马体DNA甲基化的影响，以及这些影响是否与依赖海马体的认知指标以及参与认知指标的海马体分子指标相关。我们还将讨论辐射诱导的海马体DNA甲基化变化在不同剂量的重离子照射以及不同离子照射之间是否存在重叠。我们还将讨论DNA甲基化变化是否表现出组织依赖性反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000b/11270359/b6c65a26f798/epigenomes-08-00027-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000b/11270359/66448454f020/epigenomes-08-00027-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000b/11270359/2a4189ffe8a6/epigenomes-08-00027-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000b/11270359/96fd7d0a535a/epigenomes-08-00027-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000b/11270359/961ca00b72b9/epigenomes-08-00027-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000b/11270359/f29ded93303b/epigenomes-08-00027-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000b/11270359/8a356c1079cd/epigenomes-08-00027-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000b/11270359/b6c65a26f798/epigenomes-08-00027-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000b/11270359/66448454f020/epigenomes-08-00027-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000b/11270359/2a4189ffe8a6/epigenomes-08-00027-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000b/11270359/96fd7d0a535a/epigenomes-08-00027-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000b/11270359/961ca00b72b9/epigenomes-08-00027-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000b/11270359/f29ded93303b/epigenomes-08-00027-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000b/11270359/8a356c1079cd/epigenomes-08-00027-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/000b/11270359/b6c65a26f798/epigenomes-08-00027-g007.jpg

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